Integrated Functional Genomics in Mutant Mouse Models as Tools to Investigate the Complexity of Human Immunological Disease (MUGEN)
Immunological diseases encompass a wide variety of disorders, affecting a steadily increasing proportion of people living in modern societies. Immunological diseases include multiple sclerosis, systemic lupus, rheumatoid arthritis and cancer.During the past decade, dramatic advances have been made in understanding mechanisms regulating the immune system, its pathological processes, and processes of immune deviation. As such, it was recognized that systemic or organ-specific inflammatory, infectious and autoimmune conditions share basic mechanisms of initiation and progression. Further elucidation of these mechanisms promises to be of very high value for diagnosis and treatment of these disorders.
Novel more efficient therapeutic approaches against Crohn's disease
Using a unique murine model for human Crohn's disease, MUGEN's NoE participants [G. Kollias, D. Kontoyiannis (Fleming), W. Mόller (HZI), B. Malissen (CNRS]) identified key molecules that control T lymphocyte migration to the small intestine. Their discovery brings into focus the use of novel, more efficient therapeutic approaches against Crohn's disease.
The MUGEN management office would like to announce the first call for the 2nd MUGEN Phenotyping Technological Workshop. The workshop will take place at Manchester University on the 16th and 17th of June 2008 at the University of Manchester.
2nd MUGEN Newsletter
