Effects of Reduced Connexin43 Function on Mandibular Morphology and Osteogenesis in Mutant Mouse Models of Oculodentodigital Dysplasia

Effects of Reduced Connexin43 Function on Mandibular Morphology and Osteogenesis in Mutant Mouse Models of Oculodentodigital Dysplasia

Mutations in the gene encoding the gap-junctional protein connexin43 (Cx43) is the cause of human disease oculodentodigital dysplasia (ODDD). mandible often affected by this disease, the clinical report describes both the overgrowth of the mandible and vice versa, retrognathia.

Observations were apparently opposed to underline our relative lack of understanding of how ODDD affect the morphology of the lower jaw. Using two mouse models that mimic the mutant phenotype ODDD (I130T / + and G60S / +), we sought to uncover how the altered function of Cx43 can affect the development of the lower jaw.

Specifically, jaw newborn mice were imaged using micro-CT, to allow statistical comparison of forms. network-level comparison of the key areas of the mandible is done by using histomorphology, and we quantified the mRNA expression of some of the cartilage and bone cell differentiation markers. Both G60S / + and I130T / + mice mutant has changed the morphology of the mandibular compared to their wildtype counterparts, and morphological effects are equally locally for both mutants.

In particular, the largest phenotypic differences in mutant mice focused in areas exposed to mechanical forces, such as alveolar bone, muscle attachment sites, and the articular surface. Histological analysis revealed differences intramembranous ossification of the jaw bone both mutant mice compared to their wildtype littermates. However, the organization of chondrocytes in cartilage secondary mandible is not affected in the mutant mice. Overall, our results indicate that morphological differences seen in the jaw G60S / + and I130T / + mouse as delayed ossification and suggested that mechanical forces can exacerbate the effects of ODDD bone.

 Effects of Reduced Connexin43 Function on Mandibular Morphology and Osteogenesis in Mutant Mouse Models of Oculodentodigital Dysplasia
Effects of Reduced Connexin43 Function on Mandibular Morphology and Osteogenesis in Mutant Mouse Models of Oculodentodigital Dysplasia

XIAP Protecting retinal ganglion cells in mutant ND4 Rat Model of Leber Hereditary Optic Neuropathy

Objective: Leber hereditary optic neuropathy (LHON) is a genetic form of vision loss that occurs mainly due to a mutation in the nicotinamide adenine dinucleotide dehydrogenase (ND) subunits that make up the complex I of the electron transport chain. LHON mutations resulted in the death of retinal ganglion cell apoptosis. We tested the hypothesis that gene therapy with X-linked inhibitor of apoptosis (XIAP) will prevent retinal ganglion cell apoptosis and reduce disease progression in a mouse model of LHON induced vector that carries a mutation ND4.

Methods: Adeno associated virus (AAV) encoding full-length hemagglutinin-tagged XIAP (AAV2.HA-XIAP) or green fluorescent protein (AAV2.GFP) injected into the vitreous of DBA / 1J mice. Two weeks later, LHON phenotype induced by AAV delivery of mutant ND4 (AAV2.mND4FLAG) into the vitreous. Retinal function was assessed by electroretinography pattern. Optic nerve harvested at 4 months, and XIAP therapeutic effect on the nerve fiber layer and optic nerve integrity was evaluated using immunohistochemistry, transmission electron microscopy and magnetic resonance imaging.

Human Lupus Kidney Tissue Lysate

IHUKDLUPPTL100UG each
EUR 1413
Description: Human Lupus Kidney Tissue Lysate

cDNA - Human Diabetic Diseased Tissue: Lung

C1236152Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Skin

C1236218Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Brain

C1236035Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Colon

C1236090Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Heart

C1236122Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Liver

C1236149Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Spleen

C1236246Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Stomach

C1236248Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Pancreas

C1236188Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Esophagus

C1236106Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Whole Eye

C1236108Dia-10 10 reactions
EUR 393

cDNA - Human Diabetic Diseased Tissue: Lymph Node

C1236161Dia-10 10 reactions
EUR 393

cDNA - Human Diabetic Diseased Tissue: Bone Marrow

C1236024Dia-10 10 reactions
EUR 420

Genomic DNA - Human Diabetic Diseased Tissue: Kidney, from a single donor

D1236142Dia 50 ug
EUR 489

cDNA - Human Diabetic Diseased Tissue: Skeletal Muscle

C1236171Dia 40 reactions
EUR 729

Frozen Tissue Section - Lupus: Kidney

T1236142Lup 5 slides
EUR 587

cDNA - Human Diabetic Diseased Tissue: Visceral Adipose

C1236003VisDia-10 10 reactions
EUR 420

Paraffin Tissue Section - Lupus: Kidney

T2236142Lup 5 slides
EUR 243

cDNA - Human Diabetic Diseased Tissue: Subcutaneous Adipose

C1236003SubDia-10 10 reactions
EUR 420

Optimax First Strand cDNA Synthesis Kit

K4201100 100 rnx
EUR 424

cDNA - Human Diabetic Diseased Tissue: Small Intestine: Ileum

C1236227Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Small Intestine: Jejunum

C1236230Dia 40 reactions
EUR 729

cDNA - Human Diabetic Diseased Tissue: Small Intestine: Duodenum

C1236101Dia 40 reactions
EUR 729

M-MuLV First Strand cDNA Synthesis Kit

K5147-100Rxns 100Rxns
EUR 338.8
Description: Biotechnology

cDNA - Human Tumor Tissue: Kidney

C1235142 40 reactions
EUR 578

igScript First Strand cDNA Synthesis Kit - 25 Reactions

4312 1/EA
EUR 178.8

igScript First Strand cDNA Synthesis Kit - 100 Reactions

4314 1/EA
EUR 453.6

cDNA - Human Adult Normal Tissue: Kidney

C1234142 40 reactions
EUR 385

Kidney disease spectrum (kidney cancer progression) tissue array

BC07001 each
EUR 258
Description: Kidney disease spectrum (kidney cancer progression) tissue array, including TNM and pathology grade, 40 cases/80 cores (core size 1.5mm)

cDNA - Rat Normal Tissue: Kidney

C1434142 40 reactions
EUR 385

cDNA - Dog Normal Tissue: Kidney

C1734142 40 reactions
EUR 385

cDNA - Mouse Normal Tissue: Kidney

C1334142 40 reactions
EUR 385

Accuris qMAX First Strand cDNA Synthesis Flex Kit, 200 reactions

PR2110-200 1 PC
EUR 422.5

Accuris qMAX First Strand cDNA Synthesis Flex Kit, 50 reactions

PR2110-50 1 PC
EUR 104.8

Multiple kidney disease with kidney tissue array (2016/ISUP WHO classification

KD804a each
EUR 258
Description: Multiple kidney disease with kidney tissue array (2016/ISUP WHO classification, Grade mean Isup Grade), including pathoogy grade, TNM and clinical stage (reference AJCC 8th version), 75 cases/80 cores, replacing KD804

cDNA - Monkey (Rhesus) Normal Tissue: Kidney

C1534142 40 reactions
EUR 385

Accuris qMAX First Strand cDNA Synthesis Flex Kit, sample, 5 reactions

PR2110-S 1 PC
EUR 11.8

cDNA - Monkey (Cynomolgus) Normal Tissue: Kidney

C1534142-Cy 40 reactions
EUR 385

Frozen Tissue Section - Human Diabetic Diseased Tissue: Eye

T1236108Dia 5 slides
EUR 662

Frozen Tissue Section - Human Diabetic Diseased Tissue: Lung

T1236152Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Skin

T1236218Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Brain

T1236035Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Colon

T1236090Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Heart

T1236122Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Liver

T1236149Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Spleen

T1236246Dia 5 slides
EUR 475

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Lung

T2236152Dia 5 slides
EUR 238

Frozen Tissue Section - Human Diabetic Diseased Tissue: Adrenal

T1236004Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Stomach

T1236248Dia 5 slides
EUR 475

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Colon

T2236090Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Liver

T2236149Dia 5 slides
EUR 238

Frozen Tissue Section - Human Diabetic Diseased Tissue: Pancreas

T1236188Dia 5 slides
EUR 475

Frozen Tissue Section - Human Diabetic Diseased Tissue: Esophagus

T1236106Dia 5 slides
EUR 475

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Stomach

T2236248Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Esophagus

T2236106Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Pancreas

T2236188Dia 5 slides
EUR 238

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Parathyroid

T2236189Dia 5 slides
EUR 629

cDNA - Human Tumor Tissue: Lymphoma, Hodgkin's Disease

C1235161A-10 10 reactions
EUR 274

Frozen Tissue Section - Human Diabetic Diseased Tissue: Bone Marrow

T1236024Dia 5 slides
EUR 662

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Bone Marrow

T2236024Dia 5 slides
EUR 238

Matched Pair - cDNA - Human Primary Tumor and Normal Tissue: Kidney

C8235142-PP 10 reactions x2
EUR 530

Total Protein - Human Diabetic Diseased Tissue: Lung

P1236152Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Skin

P1236218Dia 1 mg
EUR 471

Frozen Tissue Section - Human Diabetic Diseased Tissue: Visceral Adipose

T1236003VisDia 5 slides
EUR 662

Frozen Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle

T1236171Dia 5 slides
EUR 475

Total Protein - Human Diabetic Diseased Tissue: Brain

P1236035Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Colon

P1236090Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Heart

P1236122Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Liver

P1236149Dia 1 mg
EUR 471

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Skeletal Muscle

T2236171Dia 5 slides
EUR 238

Total Protein - Human Diabetic Diseased Tissue: Spleen

P1236246Dia 1 mg
EUR 471

Kidney Lupus Lysate

XBL-10357 0.1 mg
EUR 796.2
Description: Human kidney tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The human kidney tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the kidney tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The kidney tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

Total Protein - Human Diabetic Diseased Tissue: Adrenal

P1236004Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Stomach

P1236248Dia 1 mg
EUR 471

Total RNA - Lupus: Kidney

R1236142Lup-50 50 ug
EUR 421.2

Frozen Tissue Section - Human Diabetic Diseased Tissue: Subcutaneous Adipose

T1236003SubDia 5 slides
EUR 662

cDNA - Human Tumor Tissue: Lymphoma, Non-Hodgkin's Disease

C1235161B-10 10 reactions
EUR 274

Total Protein - Human Diabetic Diseased Tissue: Pancreas

P1236188Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Esophagus

P1236106Dia 1 mg
EUR 471

Frozen Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Ileum

T1236227Dia 5 slides
EUR 475

Total Protein - Lupus: Kidney

P1236142Lup 1 mg
EUR 486

Fly First-Strand cDNA Synthesis SuperMix

20-abx09885820ulSystems
  • EUR 861.60
  • EUR 693.60
  • 100 rxns × 20 ul Systems
  • 50 rxns × 20 ul Systems

Total Protein - Human Diabetic Diseased Tissue: Whole Eye

P1236108Dia 1 mg
EUR 1147

Frozen Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Jejunum

T1236230Dia 5 slides
EUR 475

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Ileum

T2236227Dia 5 slides
EUR 238

ABScript II cDNA First-Strand Synthesis Kit

RK20400 50RXN
EUR 290

miRNA First-Strand cDNA Synthesis SuperMix

abx098020-20rxns20ulSystems 20 rxns × 20 ul Systems
EUR 878.4

Frozen Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Duodenum

T1236101Dia 5 slides
EUR 475

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Jejunum

T2236230Dia 5 slides
EUR 238

Total Protein - Human Diabetic Diseased Tissue: Bone Marrow

P1236024Dia 1 mg
EUR 1147

Membrane Protein - Lupus: Kidney

P3236142Lup 0.1 mg
EUR 410

HyperScript First-Strand cDNA Synthesis Kit

K1072-100 100 rxn (20 uL/rxn)
EUR 308
Description: Synthesize first-strand cDNA from purified poly(A)+ or total RNA

HyperScript First-Strand cDNA Synthesis Kit

K1072-20 20 rxn (20 uL/rxn)
EUR 70
Description: Synthesize first-strand cDNA from purified poly(A)+ or total RNA

HyperScript First-Strand cDNA Synthesis Kit

K1072-50 50 rxn (20 uL/rxn)
EUR 164
Description: Synthesize first-strand cDNA from purified poly(A)+ or total RNA

Paraffin Tissue Section - Human Diabetic Diseased Tissue: Small Intestine: Duodenum

T2236101Dia 5 slides
EUR 238

Matched Pair - cDNA - Human Primary and Matched Metastatic Tumor Tissue: Kidney

C8235142-PM 10 reactions x2
EUR 1102

HyperScript First-Strand cDNA Synthesis SuperMix

K1073-100 100 rxn (20 uL/rxn)
EUR 352
Description: Reverse transcription reaction premixed solution for efficient synthesis of first-strand cDNA.

HyperScript First-Strand cDNA Synthesis SuperMix

K1073-50 50 rxn (20 uL/rxn)
EUR 188
Description: Reverse transcription reaction premixed solution for efficient synthesis of first-strand cDNA.

Total Protein - Human Diabetic Diseased Tissue: Skeletal Muscle

P1236171Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Visceral Adipose

P1236003VisDia 1 mg
EUR 1147

First-Strand cDNA Synthesis SuperMix (cDNA up to 12 kb)

20-abx09801620ulSystems
  • EUR 744.00
  • EUR 627.60
  • 100 rxns × 20 ul Systems
  • 50 rxns × 20 ul Systems

First-Strand cDNA Synthesis SuperMix (cDNA up to 15 kb)

20-abx09802120ulSystems
  • EUR 1045.20
  • EUR 794.40
  • 100 rxns × 20 ul Systems
  • 50 rxns × 20 ul Systems

Total Protein - Human Diabetic Diseased Tissue: Subcutaneous Adipose

P1236003SubDia 1 mg
EUR 1147

First-Strand cDNA Synthesis SuperMix for PCR

abx098018-50rxns20ulSystems 50 rxns × 20 ul Systems
EUR 693.6

Total Protein - Human Diabetic Diseased Tissue: Small Intestine: Ileum

P1236227Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Small Intestine: Duodenum

P1236101Dia 1 mg
EUR 471

Total Protein - Human Diabetic Diseased Tissue: Small Intestine: Jejunum

P1236230Dia 1 mg
EUR 471

Genomic DNA - Human Diabetic Diseased Tissue: Lung, from a single donor

D1236152Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Skin, from a single donor

D1236218Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Colon, from a single donor

D1236090Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Heart, from a single donor

D1236122Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Liver, from a single donor

D1236149Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Brain, from a single donor

D1236035Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Spleen, from a single donor

D1236246Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Stomach, from a single donor

D1236248Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Adrenal, from a single donor

D1236004Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Esophagus, from a single donor

D1236106Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Pancreas, from a single donor

D1236188Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Whole Eye, from a single donor

D1236108Dia 50 ug
EUR 1152

Genomic DNA - Human Diabetic Diseased Tissue: Bone Marrow, from a single donor

D1236024Dia 50 ug
EUR 1152

Multiple organ digestive system diseased tissue array with normal tissue as control

BCC000128 each
EUR 198
Description: Multiple organ digestive system diseased tissue array with normal tissue as control, including TNM, clinical stage and pathology grade, 40 cases/40 cores

Human Kidney Tissue Lysate

30R-AK003 150 ug
EUR 262.8
Description: Fresh tissue lysate isolated from human kidney

Human Kidney Tissue Lysate

IHUKDTL100UG each
EUR 361
Description: Human Kidney Tissue Lysate

Genomic DNA - Human Diabetic Diseased Tissue: Skeletal Muscle, from a single donor

D1236171Dia 50 ug
EUR 489

Genomic DNA - Human Diabetic Diseased Tissue: Visceral Adipose, from a single donor

D1236003VisDia 50 ug
EUR 1152

Kidney cancer with kidney tissue test tissue array

T071b each
EUR 48
Description: Kidney cancer with kidney tissue test tissue array, including pathology grade, TNM and clinical stage, 6 cases/24 cores, replacing T071a

Kidney cancer tissue array with normal Kidney tissue

KD2082a each
EUR 474
Description: Kidney cancer tissue array with normal Kidney tissue, including TNM and pathology grade, 96 cases/192 cores, replacing KD2082

Genomic DNA - Lupus: Kidney, from a single donor

D1236142Lup 50 ug
EUR 504

Genomic DNA - Human Diabetic Diseased Tissue: Subcutaneous Adipose, from a single donor

D1236003SubDia 50 ug
EUR 1152

Human Lupus Lung Tissue Lysate

IHULGLUPPTL100UG each
EUR 1413
Description: Human Lupus Lung Tissue Lysate

Genomic DNA - Human Diabetic Diseased Tissue: Small Intestine: Ileum, from a single donor

D1236227Dia 50 ug
EUR 489

Human Lupus Heart Tissue Lysate

IHUHTLUPPTL100UG each
EUR 1413
Description: Human Lupus Heart Tissue Lysate

Human Lupus Liver Tissue Lysate

IHULRLUPPTL100UG each
EUR 1413
Description: Human Lupus Liver Tissue Lysate

Human Lupus Ovary Tissue Lysate

IHUOVLUPPTL100UG each
EUR 1939
Description: Human Lupus Ovary Tissue Lysate

Human Lupus Colon Tissue Lysate

IHUCLNLUPPTL100UG each
EUR 1413
Description: Human Lupus Colon Tissue Lysate

cDNA - Lupus: Lung

C1236152Lup 40 reactions
EUR 737

Human Lupus Spleen Tissue Lysate

IHUSPLUPPTL100UG each
EUR 1413
Description: Human Lupus Spleen Tissue Lysate

Human Lupus Artery Tissue Lysate

IHUARLUPPTL100UG each
EUR 1413
Description: Human Lupus Artery Tissue Lysate

Genomic DNA - Human Diabetic Diseased Tissue: Small Intestine: Jejunum, from a single donor

D1236230Dia 50 ug
EUR 489

cDNA - Lupus: Colon

C1236090Lup 40 reactions
EUR 737

cDNA - Lupus: Heart

C1236122Lup 40 reactions
EUR 737

cDNA - Lupus: Liver

C1236149Lup 40 reactions
EUR 737

Human Lupus Vaginal Tissue Lysate

IHUVAGLUPPTL100UG each
EUR 1413
Description: Human Lupus Vaginal Tissue Lysate

cDNA - Lupus: Spleen

C1236246Lup 40 reactions
EUR 737

Kidney cancer tissue array with adjacent normal kidney tissue

BC07015b each
EUR 168
Description: Kidney cancer tissue array with adjacent normal kidney tissue, including TNM, clinical stage and pathology grade, 72 cases/72 cores, replacing BC07015a

Human Lupus Pancreas Tissue Lysate

IHUPCSLUPPTL100UG each
EUR 1413
Description: Human Lupus Pancreas Tissue Lysate

Human Lupus Appendix Tissue Lysate

IHUAPXLUPPTL100UG each
EUR 1413
Description: Human Lupus Appendix Tissue Lysate

Human Kidney Fetal Tissue Lysate

IHUKDFSTL100UG each
EUR 541
Description: Human Kidney Fetal Tissue Lysate

HyperScript First-Strand cDNA Synthesis SuperMix (with gDNA wiper)

K1173-100 100 rxns
EUR 380
Description: Reverse transcription reaction premixed solution for efficient synthesis of first-strand cDNA.

HyperScript First-Strand cDNA Synthesis SuperMix (with gDNA wiper)

K1173-50 50 rxns
EUR 220
Description: Reverse transcription reaction premixed solution for efficient synthesis of first-strand cDNA.

Genomic DNA - Human Diabetic Diseased Tissue: Small Intestine: Duodenum, from a single donor

D1236101Dia 50 ug
EUR 489

cDNA - Lupus: stomach

C1236248Lup 40 reactions
EUR 737

Kidney tissue array

KD803b each
EUR 354
Description: Kidney tissue array, 80 cases/80n cores (core size 1.5mm), replacing KD803a

cDNA - Lupus: Pancreas

C1236188Lup 40 reactions
EUR 737

All-in-One First-Strand cDNA Synthesis SuperMix for PCR

abx098023-50rxns20ulSystems 50 rxns × 20 ul Systems
EUR 878.4

Human Lupus Pericardium Tissue Lysate

IHUPRCLUPPTL100UG each
EUR 1413
Description: Human Lupus Pericardium Tissue Lysate

Human Kidney OptiTDS1: Tissue Dissociation System

4-28074 1 Kit Ask for price

Human Kidney OptiTDS2: Tissue Dissociation System

4-28075 1 Kit Ask for price

Human Kidney OptiTDS3: Tissue Dissociation System

4-28076 1 Kit Ask for price

Human Kidney OptiTDS4: Tissue Dissociation System

4-28077 1 Kit Ask for price

Human Kidney OptiTDS5: Tissue Dissociation System

4-28078 1 Kit Ask for price

Human Kidney OptiTDS6: Tissue Dissociation System

4-28079 1 Kit Ask for price

Human Kidney OptiTDS7: Tissue Dissociation System

4-28080 1 Kit Ask for price

First.Strand cDNA PLUS Synthesis Kit (20 µl / reaction)

105-560 20 rcs
EUR 122.4

Results: During the development of LHON disease, retinal ganglion cell axons lost. Body core apoptotic cells seen in astrocytes or oligodendrocytes in the optic nerve, and there is thinning of the optic nerve and retinal nerve fiber layer. At 4 months after the onset of illness, XIAP gene therapy protects the nerve fiber layer and optic nerve architecture by maintaining healthy axons. XIAP also decreased nuclear fragmentation in the population of astrocytes or oligodendrocytes and reduce infiltration of glial cells.