Improving interpretation of genetic testing for hereditary hemorrhagic, thrombotic, and platelet disorders

0 Comments
Improving interpretation of genetic testing for hereditary hemorrhagic, thrombotic, and platelet disorders

The final 10 years have seen an explosion within the quantity of knowledge out there by next-generation sequencing. These knowledge are advancing rapidly, and this tempo makes it tough for many practitioners to simply sustain with all the new info. Complicating this understanding is usually conflicting details about variant pathogenicity and even in regards to the function of some genes within the pathogenesis of illness. The extra widespread medical use of sequencing has expanded phenotypes, together with the identification of gentle phenotypes related to beforehand critical illness, akin to with some variants in RUNX1, MYH9, ITG2A, and others.

 

A number of organizations have taken up the duty of cataloging and systematically evaluating genes and variants utilizing a standardized strategy and making the info publicly out there in order that others can profit from their gene/variant curation. The efforts in testing for hereditary hemorrhagic, thrombotic, and platelet problems have been led by the Worldwide Society on Thrombosis and Haemostasis Scientific Standardization Committee on Genomics in Thrombosis and Hemostasis, the American Society of Hematology, and the Nationwide Institutes of Well being Nationwide Human Genome Analysis Institute Scientific Genome Useful resource. This text outlines present efforts to enhance the interpretation of genetic testing and the function of standardizing and disseminating info.

By assessing the energy of gene-disease associations, standardizing variant curation tips, sharing genomic knowledge amongst knowledgeable members, and incorporating knowledge from present illness databases, the variety of variants of unsure significance will lower, thereby bettering the worth of genetic testing as a diagnostic software.

 Improving interpretation of genetic testing for hereditary hemorrhagic, thrombotic, and platelet disorders

Improving interpretation of genetic testing for hereditary hemorrhagic, thrombotic, and platelet disorders

Transcriptomic and proteomic analyses of a brand new cytoplasmic male sterile line with a wild Gossypium bickii genetic background

Background: Cotton is a crucial fiber crop however has critical heterosis results, and cytoplasmic male sterility (CMS) is the most important explanation for heterosis in vegetation. Nevertheless, to the very best of our information, no research have investigated CMS Yamian A in cotton with the genetic background of Australian wild Gossypium bickii. Conjoint transcriptomic and proteomic evaluation was first carried out between Yamian A and its maintainer Yamian B.
Outcomes: We detected 550 differentially expressed transcript-derived fragments (TDFs) and at the very least 1013 proteins in anthers at varied developmental levels. Forty-two TDFs and 11 differentially expressed proteins (DEPs) have been annotated by evaluation within the genomic databases of G. austral, G. arboreum and G. hirsutum. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses have been carried out to raised perceive the features of those TDFs and DEPs. Transcriptomic and proteomic outcomes confirmed that UDP-glucuronosyl/UDP-glucosyltransferase, 60S ribosomal protein L13a-4-like, and glutathione S-transferase have been upregulated; whereas warmth shock protein Hsp20, ATPase, F0 complicated, and subunit D have been downregulated on the microspore abortion stage of Yamian A.
As well as, a number of TDFs from the transcriptome and several other DEPs from the proteome have been detected and confirmed by quantitative real-time PCR as being expressed within the buds of seven completely different durations of growth. We established the databases of differentially expressed genes and proteins between Yamian A and its maintainer Yamian B within the anthers at varied developmental levels and constructed an interplay community primarily based on the databases for a complete understanding of the mechanism underlying CMS with a wild cotton genetic background.
Conclusion: We first analyzed the molecular mechanism of CMS Yamian A from the attitude of omics, thereby offering an experimental foundation and theoretical basis for future analysis trying to investigate the abortion mechanism of recent CMS with a wild Gossypium bickii background and to appreciate three-line matching.

Genome-wide transcriptome variation panorama in Ruta chalepensis organs revealed potential genes chargeable for rutin biosynthesis

Ruta chalepensis L., mostly often known as ‘fringed rue,’ is a wonderful and useful bioactive plant that produces a spread of complicated flavonoids, of which rutin is the most important compound current on this plant of nice pharmaceutical and medicinal significance. The current research is a pioneering try to look at the modifications within the transcriptomic panorama of leaf, stem, and root tissues and correlate this with rutin amount in every tissue with a purpose to establish the candidate genes chargeable for rutin biosynthesis and to extend genomic assets in fringed rue.
Comparative transcriptome sequencing of leaves, stems and roots have been carried out utilizing the NovaSeq 6000 platform. The de novo transcriptome meeting generated 254,685 transcripts representing 154,018 genes with GC content material of 42.60% and N50 of 2280 bp. Looking assembled transcripts in opposition to UniRef90 and SwissProt databases annotated 79.7% of them as protein coding. The leaf tissues had the very best rutin content material adopted by stems and roots. A number of differentially expressed genes and transcripts regarding rutin biosynthesis have been recognized in leaves evaluating with roots or stems evaluating with roots. All of the genes identified to be concerned in rutin biosynthesis confirmed up-regulation in leaves as in contrast with roots.

Syringe Connector

SCEB-1 1/pk
EUR 68.4

Connector PTFE

Q4510/04 PK10
EUR 105.63

100 bp DNA Ladder (100 bp ~ 1,500 bp, with loading dye)

W0636-100 - Ask for price

Universal DNA Marker (100 bp ~ 10,000 bp)

W2583-100 - Ask for price

Universal DNA Marker (100 bp ~ 10,000 bp)

W2583-50 - Ask for price

Universal DNA Marker (100 bp ~ 10,000 bp)

W2583-500 - Ask for price

50/100 bp DNA Ladder (50 bp ~ 1,500 bp, with loading dye)

W109-100 - Ask for price

PIPET CONTROLLER CONNECTOR

357478 1/pk
EUR 40.8
Description: Falcon Liquid Handling Equipment; Falcon Pipet Controllers and Accessories

Male FPLC Connector

MFC-1 1/pk
EUR 93.6

Female FPLC Connector

FFC-1 1/pk
EUR 93.6

Connector Unequal 8121416mm

CON7084 PK10
EUR 22.8

Duran Connector Assembly

FLA3940 PK10
EUR 72.96

PR antibody

70R-36087 100 ug
EUR 392.4
Description: Rabbit polyclonal PR antibody

PR antibody

70R-36593 100 ug
EUR 392.4
Description: Rabbit polyclonal PR antibody

PR antibody

70R-13954 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal PR antibody

PR antibody

10R-1954 100 ul
EUR 418.8
Description: Mouse monoclonal PR antibody

PR-619

A8212-100 100 mg
EUR 448.8
Description: (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate, also designated as PR-619, is a broad-range reversible and cell-permeable inhibitor of deubiquitylating enzyme (DUB)[1][2][3], potently suppresses the activity of almost all cysteine protease DUBs[4].

PR-619

A8212-25 25 mg
EUR 199.2
Description: (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate, also designated as PR-619, is a broad-range reversible and cell-permeable inhibitor of deubiquitylating enzyme (DUB)[1][2][3], potently suppresses the activity of almost all cysteine protease DUBs[4].

PR-619

A8212-5 5 mg
EUR 115.2
Description: (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate, also designated as PR-619, is a broad-range reversible and cell-permeable inhibitor of deubiquitylating enzyme (DUB)[1][2][3], potently suppresses the activity of almost all cysteine protease DUBs[4].

PR-619

A8212-5.1 10 mM (in 1mL DMSO)
EUR 170.4
Description: (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate, also designated as PR-619, is a broad-range reversible and cell-permeable inhibitor of deubiquitylating enzyme (DUB)[1][2][3], potently suppresses the activity of almost all cysteine protease DUBs[4].

PR-619

A8212-S Evaluation Sample
EUR 97.2
Description: (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate, also designated as PR-619, is a broad-range reversible and cell-permeable inhibitor of deubiquitylating enzyme (DUB)[1][2][3], potently suppresses the activity of almost all cysteine protease DUBs[4].

PR Antibody

BF0581 200ul
EUR 540

PR-619

HY-13814 50mg
EUR 439.2

PR Antibody

F53580-0.1ML 0.1 ml
EUR 379

PR Antibody

F47198-0.4ML 0.4 ml
EUR 379

PR Antibody

F47596-0.4ML 0.4 ml
EUR 379

CREB-BP Antibody

33346-100ul 100ul
EUR 302.4

CREB-BP Antibody

33346-50ul 50ul
EUR 224.4

epsilon BP Antibody

abx018318-100ug 100 ug
EUR 460.8

CREB- BP Antibody

ABF0139 100 ug
EUR 525.6

PPAR- BP Antibody

ABF6446 100 ug
EUR 525.6

BP-1 Protein

20-abx263543
  • EUR 994.80
  • EUR 493.20
  • EUR 644.40
  • 10 ug
  • 2 µg
  • 5 ug

BP 554 maleate

B6351-10 10 mg
EUR 321.6
Description: BP-554 maleate is a selective agonist of 5-HT1A receptor [1]. The 5-HT1A receptor is a G protein-coupled receptor for endogenous neurotransmitter serotonin (5-HT) and mediates inhibitory neurotransmission. BP-554 maleate is a selective 5-HT1A receptor agonist.

BP 554 maleate

B6351-50 50 mg
EUR 1167.6
Description: BP-554 maleate is a selective agonist of 5-HT1A receptor [1]. The 5-HT1A receptor is a G protein-coupled receptor for endogenous neurotransmitter serotonin (5-HT) and mediates inhibitory neurotransmission. BP-554 maleate is a selective 5-HT1A receptor agonist.

CREB-BP Antibody

AF0139 200ul
EUR 420

CREB-BP Antibody

AF0861 200ul
EUR 420

BP-1-102

HY-100493 100mg
EUR 1614

Naproxen, BP grade

GP6640-25G 25 g
EUR 208.8

PIPET CONTROLLER CONNECTOR GASKET

357477 1/pk
EUR 42
Description: Falcon Liquid Handling Equipment; Falcon Pipet Controllers and Accessories

Hose Connector Duran 9mm

2925506 PK10
EUR 17.1

Connector Straight PP 35mm

CON7060 PK10
EUR 7.98

Connector Straight PP 48mm

CON7062 PK10
EUR 28.5

Connector Straight PP 610mm

CON7064 PK10
EUR 38.76

Connector Straight PP 812mm

CON7066 PK10
EUR 39.9

Connector Straight PP 1014mm

CON7068 PK10
EUR 17.1

Connector Unequal 4810 12mm

CON7080 PK10
EUR 17.1

Connector Unequal 4812 16mm

CON7082 PK10
EUR 18.24

Portex Connector 4mm Straight

CON7240 PK10
EUR 19.15

Portex Connector 6mm Straight

CON7242 PK10
EUR 20.35

Portex Connector 10.5mm Straight

CON7244 PK10
EUR 19.04

Connector 2m POD-POD

ZFC0NN2QQ EACH
EUR 135.66

Connector 5m POD-POD

ZFC0NN5QQ EACH
EUR 135.66

Connector 5m System-POD

ZFC0NN5SQ EACH
EUR 135.66

Screwthread Connector PTFE Quickfit

Q451002 PK10
EUR 77.29

PR antibody (Ser294)

70R-35360 100 ug
EUR 392.4
Description: Purified Rabbit polyclonal PR antibody (Ser294)

PR antibody (Ser400)

70R-36239 100 ug
EUR 392.4
Description: Rabbit polyclonal PR antibody (Ser400)

PR Monoclonal Antibody

40481-100ul 100ul
EUR 302.4

PR Monoclonal Antibody

40481-50ul 50ul
EUR 224.4

PR Polyclonal Antibody

ABP55582-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PR from Human, Mouse, Rat. This PR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PR around the non-phosphorylation site of S294

PR Polyclonal Antibody

ABP55582-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PR from Human, Mouse, Rat. This PR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PR around the non-phosphorylation site of S294

PR Polyclonal Antibody

ABP55582-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PR from Human, Mouse, Rat. This PR antibody is for IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PR around the non-phosphorylation site of S294

PR Polyclonal Antibody

ABP55583-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PR from Human, Monkey. This PR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PR around the non-phosphorylation site of S190

PR Polyclonal Antibody

ABP55583-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PR from Human, Monkey. This PR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PR around the non-phosphorylation site of S190

PR Polyclonal Antibody

ABP55583-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PR from Human, Monkey. This PR antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PR around the non-phosphorylation site of S190

Pr-Set7 Antibody

20-abx142078
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

PR Polyclonal Antibody

ABP52256-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of PR from Human. This PR antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PR around the non-phosphorylation site of S400

PR Polyclonal Antibody

ABP52256-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of PR from Human. This PR antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PR around the non-phosphorylation site of S400

PR Polyclonal Antibody

ABP52256-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of PR from Human. This PR antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human PR around the non-phosphorylation site of S400

PR-4b Antibody

abx018530-100ul 100 ul
EUR 460.8

PR-1 Antibody

abx018531-100ul 100 ul
EUR 460.8

PR-pha Antibody

abx018532-100ul 100 ul
EUR 460.8

PR-3 Antibody

abx018533-100ul 100 ul
EUR 460.8

PR-15 Antibody

abx018534-100ul 100 ul
EUR 460.8

PR-10c Antibody

abx018535-100ul 100 ul
EUR 460.8

PR-2 Antibody

abx018536-100ul 100 ul
EUR 460.8

PR-8 Antibody

abx018537-100ul 100 ul
EUR 460.8

PR-16 Antibody

abx018538-100ul 100 ul
EUR 460.8

PR-6 Antibody

abx018539-100ul 100 ul
EUR 460.8

PR-10d Antibody

abx018540-100ul 100 ul
EUR 460.8

PR-1a Antibody

abx018542-100ul 100 ul
EUR 460.8

PR-1b Antibody

abx018543-100ul 100 ul
EUR 460.8

PR-10e Antibody

abx018544-100ul 100 ul
EUR 460.8

PR Monoclonal Antibody

ABM40184-003ml 0.03ml
EUR 189.6
Description: A monoclonal antibody for detection of PR from Human, Mouse, Rat. This PR antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PR Monoclonal Antibody

ABM40184-01ml 0.1ml
EUR 346.8
Description: A monoclonal antibody for detection of PR from Human, Mouse, Rat. This PR antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

PR Monoclonal Antibody

ABM40184-02ml 0.2ml
EUR 496.8
Description: A monoclonal antibody for detection of PR from Human, Mouse, Rat. This PR antibody is for IHC-P, IF. It is affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide

Carfilzomib (PR-171)

A1933-10 10 mg
EUR 309.6
Description: An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins.

Carfilzomib (PR-171)

A1933-25 25 mg
EUR 477.6
Description: An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins.

Carfilzomib (PR-171)

A1933-5 5 mg
EUR 226.8
Description: An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins.

Carfilzomib (PR-171)

A1933-5.1 10 mM (in 1mL DMSO)
EUR 268.8
Description: An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins.

Carfilzomib (PR-171)

A1933-S Evaluation Sample
EUR 97.2
Description: An epoxomicin derivate with potential antineoplastic activity. It irreversibly binds to and inhibits the chymotrypsin-like activity of the 20S proteasome, an enzyme responsible for degrading a large variety of cellular proteins.

PR repeat Antibody

abx236744-100ug 100 ug
EUR 661.2

PR 39 (porcine)

B5241-.5 500 ug
EUR 673.2

PR Polyclonal Antibody

ES3255-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PR from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

PR Polyclonal Antibody

ES3255-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PR from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Anti-PR antibody

PAab09774 100 ug
EUR 426

anti-PR (2F12B4)

LF-MA30089 100 ul
EUR 534
Description: Mouse Monoclonal to PR

anti- PR antibody

FNab09774 100µg
EUR 658.5
Description: Antibody raised against PR

PR Polyclonal Antibody

ES6581-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PR from Human/Mouse/Rat. This antibody is tested and validated for IHC, IF, WB, ELISA

PR Polyclonal Antibody

ES6581-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PR from Human/Mouse/Rat. This antibody is tested and validated for IHC, IF, WB, ELISA

PR Polyclonal Antibody

ES6582-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against PR from Human/Monkey. This antibody is tested and validated for WB, ELISA, WB, ELISA

PR Polyclonal Antibody

ES6582-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against PR from Human/Monkey. This antibody is tested and validated for WB, ELISA, WB, ELISA

Anti-PR antibody

STJ98331 100 µl
EUR 280.8
Description: Mouse monoclonal to PR.

Anti-PR antibody

STJ98332 100 µl
EUR 280.8
Description: Mouse monoclonal to PR.

Anti-PR antibody

STJ98333 100 µl
EUR 280.8
Description: Mouse monoclonal to PR.

Anti-PR antibody

STJ95208 200 µl
EUR 236.4
Description: Rabbit polyclonal to PR.

Anti-PR antibody

STJ95209 200 µl
EUR 236.4
Description: Rabbit polyclonal to PR.

Anti-PR antibody

STJ95210 200 µl
EUR 236.4
Description: Rabbit polyclonal to PR.

Anti-PR antibody

STJ97365 200 µl
EUR 236.4
Description: PR is a protein encoded by the PGR gene which is approximately 98,9 kDa. PR is localised to the nucleus and cytoplasm. It is involved in the oocyte meiosis, gene expression, nuclear receptor transcription pathway and signalling by ERBB4. This protein falls under the steroid receptor superfamily. It mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is expressed in the heart, lymph nodes, muscle, blood and nervous system. Mutations in the PGR gene may result in progesterone resistance. STJ97365 was developed from clone Z15 and was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. The antibody detects endogenous PR protein.

Anti-PR antibody

STJ180227 0.1 ml
EUR 309.6

FITTING KIT PR

ZAFSKITPR EACH
EUR 253.08

Recombinant Human BP-1

7-04579 2µg Ask for price

Recombinant Human BP-1

7-04580 5µg Ask for price

Recombinant Human BP-1

7-04581 10µg Ask for price

Ran BP-1 antibody

22886-100ul 100ul
EUR 468

AI-BP Polyclonal Antibody

ABP50614-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AI-BP from Human, Mouse, Rat. This AI-BP antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AI-BP at AA range: 90-170

AI-BP Polyclonal Antibody

ABP50614-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AI-BP from Human, Mouse, Rat. This AI-BP antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AI-BP at AA range: 90-170

AI-BP Polyclonal Antibody

ABP50614-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AI-BP from Human, Mouse, Rat. This AI-BP antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AI-BP at AA range: 90-170

IL18 BP Recombinant Protein

96-467 0.2 mg
EUR 588.3
Description: Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.

IL18 BP Recombinant Protein

96-469 0.2 mg
EUR 651.3
Description: Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.

Anti-CREB-BP Antibody

A00205 100ul
EUR 476.4
Description: Rabbit Polyclonal CREB-BP Antibody. Validated in IF, IHC, WB and tested in Human.

CREB-BP Conjugated Antibody

C33346 100ul
EUR 476.4

AI-BP Polyclonal Antibody

ES1613-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AI-BP from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

AI-BP Polyclonal Antibody

ES1613-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AI-BP from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

Rabbit BP ELISA Kit

ERTB0690 96Tests
EUR 625.2
These outcomes have been confirmed by gene ontology (GO) and pathway enrichment analyses. Up-regulated genes in leaves as in contrast with roots enriched GO phrases with relation to rutin biosynthesis e.g. motion of flavonol synthase, biosynthetic mechanism of malonyl-CoA, and motion of monooxygenase. Phylogenetic evaluation of the Rhamnosyltransferase (RT) gene confirmed that it was extremely homologues with RT sequence from Citrus species and all have been positioned in the identical clade. This transcriptomic dataset will function an vital public useful resource for future genomics and transcriptomic research in R. chalepensis and can act as a benchmark for the dentification and genetic modification of genes concerned within the biosynthesis of secondary metabolites.

Leave a Reply

Your email address will not be published.