Organoarsenicals inhibit bacterial peptidoglycan biosynthesis by concentrating on the important enzymeMurA
Javier
September 25, 2020
Salivary antioxidant enzymes related to oral toxicity in haematopoietic cell transplantation: An observational research
Background: In haematopoietic cell transplantation (HCT), oral mucositis and xerostomia are associated to conditioning-related oxidative stress. The function of salivary antioxidant enzymes in oral toxicity is poorly described. The purpose of this research was to confirm the affiliation between salivary antioxidant enzymes and oral mucositis and xerostomia in HCT.
Design: Saliva from autologous and allogeneic HCT sufferers (n = 77) was chosen earlier than conditioning (T0), in the course of the neutropenia interval (T1) and after marrow engraftment (T2). Salivary circulate, complete salivary proteins, and superoxide dismutase, catalase and glutathione reductase actions had been measured.
Outcomes: There have been no important variations in salivary circulate , complete salivary proteins and catalase on the three HCT time factors. Glutathione reductase ranges had been diminished at T1 in comparison with T0 (P = .013) and T2 (P = .001). Superoxide dismutase ranges had been elevated from T0 to T2 (P = .013). Neither of those enzymes was related to oral mucositis. Elevated superoxide dismutase ranges had been related to xerostomia frequency. Ranges of this enzyme additionally confirmed important correlation with days of xerostomia in T2 (ρ = .40, P = .002).
Conclusions: Salivary antioxidant enzymes modified earlier than and through early durations after HCT. The rise in salivary superoxide dismutase advised partial activation of the salivary antioxidant system and was related to xerostomia.
mugen-noe
Bovine mRNA- decapping enzyme 1B, DCP1B ELISA KIT
ELI-32403b
Lifescience Market
96 Tests
EUR 1113.6
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B)
MBS641446-02mL
MyBiosource
0.2mL
EUR 695
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B)
MBS641446-5x02mL
MyBiosource
5x0.2mL
EUR 2975
DCP1B (untagged)-Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B)
SC126398
Origene Technologies GmbH
10 µg
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DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (AP)
MBS6291145-02mL
MyBiosource
0.2mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (AP)
MBS6291145-5x02mL
MyBiosource
5x0.2mL
EUR 4250
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (PE)
MBS6291155-02mL
MyBiosource
0.2mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (PE)
MBS6291155-5x02mL
MyBiosource
5x0.2mL
EUR 4250
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (APC)
MBS6291146-02mL
MyBiosource
0.2mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (APC)
MBS6291146-5x02mL
MyBiosource
5x0.2mL
EUR 4250
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (FITC)
MBS6291148-02mL
MyBiosource
0.2mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (FITC)
MBS6291148-5x02mL
MyBiosource
5x0.2mL
EUR 4250
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (Biotin)
MBS6291147-02mL
MyBiosource
0.2mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (Biotin)
MBS6291147-5x02mL
MyBiosource
5x0.2mL
EUR 4250
Dcp1b (untagged) - Mouse DCP1 decapping enzyme homolog b (S. cerevisiae) (Dcp1b), (10ug)
MC219240
Origene Technologies GmbH
10 µg
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DCP1B (GFP-tagged) - Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B)
RG207398
Origene Technologies GmbH
10 µg
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Dcp1b (Myc-DDK-tagged) - Mouse DCP1 decapping enzyme homolog b (S. cerevisiae) (Dcp1b)
MR218839
Origene Technologies GmbH
10 µg
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Dcp1b (GFP-tagged) - Mouse DCP1 decapping enzyme homolog b (S. cerevisiae) (Dcp1b), (10ug)
MG218839
Origene Technologies GmbH
10 µg
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DCP1B (Myc-DDK-tagged)-Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B)
RC207398
Origene Technologies GmbH
10 µg
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DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (MaxLight 405)
MBS6291150-01mL
MyBiosource
0.1mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (MaxLight 405)
MBS6291150-5x01mL
MyBiosource
5x0.1mL
EUR 4250
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (MaxLight 490)
MBS6291151-01mL
MyBiosource
0.1mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (MaxLight 490)
MBS6291151-5x01mL
MyBiosource
5x0.1mL
EUR 4250
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (MaxLight 550)
MBS6291152-01mL
MyBiosource
0.1mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (MaxLight 550)
MBS6291152-5x01mL
MyBiosource
5x0.1mL
EUR 4250
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (MaxLight 650)
MBS6291153-01mL
MyBiosource
0.1mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (MaxLight 650)
MBS6291153-5x01mL
MyBiosource
5x0.1mL
EUR 4250
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (MaxLight 750)
MBS6291154-01mL
MyBiosource
0.1mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (MaxLight 750)
MBS6291154-5x01mL
MyBiosource
5x0.1mL
EUR 4250
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (Azide free) (HRP)
MBS6291149-02mL
MyBiosource
0.2mL
EUR 980
DCP1B, ID (DCP1B, mRNA-decapping enzyme 1B) (Azide free) (HRP)
MBS6291149-5x02mL
MyBiosource
5x0.2mL
EUR 4250
Lenti ORF clone of Dcp1b (mGFP-tagged) - Mouse DCP1 decapping enzyme homolog b (S. cerevisiae) (Dcp1b)
MR218839L4
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Dcp1b (Myc-DDK-tagged) - Mouse DCP1 decapping enzyme homolog b (S. cerevisiae) (Dcp1b)
MR218839L3
Origene Technologies GmbH
10 µg
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Lenti ORF particles, Dcp1b (GFP-tagged) - Mouse DCP1 decapping enzyme homolog b (S. cerevisiae) (Dcp1b), 200ul, >10^7 TU/mL
MR218839L4V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, DCP1B (mGFP-tagged) - Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B), 200ul, >10^7 TU/mL
RC207398L2V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, DCP1B (mGFP-tagged) - Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B), 200ul, >10^7 TU/mL
RC207398L4V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, Dcp1b (Myc-DDK-tagged) - Mouse DCP1 decapping enzyme homolog b (S. cerevisiae) (Dcp1b), 200ul, >10^7 TU/mL
MR218839L3V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, DCP1B (Myc-DDK tagged) - Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B), 200ul, >10^7 TU/mL
RC207398L1V
Origene Technologies GmbH
200 µl
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Lenti ORF particles, DCP1B (Myc-DDK tagged) - Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B), 200ul, >10^7 TU/mL
RC207398L3V
Origene Technologies GmbH
200 µl
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Human mRNA-decapping enzyme 1B (DCP1B)
1-CSB-CF811635HU
Cusabio
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Description: Recombinant Human mRNA-decapping enzyme 1B(DCP1B) expressed in in vitro E.coli expression system
Human mRNA-decapping enzyme 1B (DCP1B)
1-CSB-YP811635HU
Cusabio
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10ug
50ug
100ug
200ug
500ug
1MG
Description: Recombinant Human mRNA-decapping enzyme 1B(DCP1B) expressed in Yeast
mRNA-Decapping Enzyme 1B (DCP1B) Antibody
abx111966-100l
Abbexa
100 µl
EUR 612.5
mRNA-Decapping Enzyme 1B (DCP1B) Antibody
20-abx111966
Abbexa
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mRNA-Decapping Enzyme 1B (DCP1B) Antibody
abx232270-100g
Abbexa
100 µg
EUR 350
mRNA-Decapping Enzyme 1B (DCP1B) Antibody
abx232270-100ug
Abbexa
100 ug
EUR 610.8
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (AP)
MBS6413670-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (AP)
MBS6413670-5x01mL
MyBiosource
5x0.1mL
EUR 4120
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (PE)
MBS6413680-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (PE)
MBS6413680-5x01mL
MyBiosource
5x0.1mL
EUR 4120
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (APC)
MBS6413671-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (APC)
MBS6413671-5x01mL
MyBiosource
5x0.1mL
EUR 4120
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (HRP)
MBS6413674-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (HRP)
MBS6413674-5x01mL
MyBiosource
5x0.1mL
EUR 4120
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (FITC)
MBS6413673-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (FITC)
MBS6413673-5x01mL
MyBiosource
5x0.1mL
EUR 4120
Lenti ORF clone of Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B), mGFP tagged
RC207398L2
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B), mGFP tagged
RC207398L4
Origene Technologies GmbH
10 µg
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DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (Biotin)
MBS6413672-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (Biotin)
MBS6413672-5x01mL
MyBiosource
5x0.1mL
EUR 4120
Recombinant Human mRNA-decapping enzyme 1B(DCP1B)
AP78237
SAB
each
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Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
CSB-CF811635HU
Cusabio
432 mg
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Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
CSB-CF811635HU-100ug
Cusabio
100ug
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Description: 2-617aa
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
CSB-CF811635HU-20ug
Cusabio
20ug
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Description: 2-617aa
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
CSB-CF811635HU-each
Cusabio
each
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Description: 2-617aa
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
CSB-YP811635HU
Cusabio
6608 mg
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Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
CSB-YP811635HU-20ug
Cusabio
20ug
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Description: 2-617aa
Recombinant Human mRNA-decapping enzyme 1B(DCP1B)
AP74579
SAB
each
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Recombinant Mouse mRNA-decapping enzyme 1B (Dcp1b)
MBS1360933-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1435
Recombinant Mouse mRNA-decapping enzyme 1B (Dcp1b)
MBS1360933-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 1125
Recombinant Mouse mRNA-decapping enzyme 1B (Dcp1b)
MBS1360933-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 1195
Recombinant Mouse mRNA-decapping enzyme 1B (Dcp1b)
MBS1360933-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 1355
Recombinant Mouse mRNA-decapping enzyme 1B (Dcp1b)
MBS1360933-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1405
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS1370061-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 360
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS1370061-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 610
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS1370061-05mgYeast
MyBiosource
0.5mg(Yeast)
EUR 1505
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS1370061-5x05mgYeast
MyBiosource
5x0.5mg(Yeast)
EUR 6565
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS7053565-002mg
MyBiosource
0.02mg
EUR 735
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS7053565-01mg
MyBiosource
0.1mg
EUR 1350
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS7053565-5x01mg
MyBiosource
5x0.1mg
EUR 5880
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS9424159-002mg
MyBiosource
0.02mg
EUR 440
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS9424159-01mg
MyBiosource
0.1mg
EUR 760
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS9424159-05mg
MyBiosource
0.5mg
EUR 1975
Recombinant Human mRNA-decapping enzyme 1B (DCP1B)
MBS9424159-5x05mg
MyBiosource
5x0.5mg
EUR 8735
3`UTR clone of DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B) for miRNA target validation
SC201741
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B), Myc-DDK-tagged
RC207398L1
Origene Technologies GmbH
10 µg
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Lenti ORF clone of Human DCP1 decapping enzyme homolog B (S. cerevisiae) (DCP1B), Myc-DDK-tagged
RC207398L3
Origene Technologies GmbH
10 µg
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Mouse mRNA- decapping enzyme 2, Dcp2 ELISA KIT
ELI-26523m
Lifescience Market
96 Tests
EUR 1038
Human mRNA- decapping enzyme 2, DCP2 ELISA KIT
ELI-09113h
Lifescience Market
96 Tests
EUR 988.8
Mouse mRNA- decapping enzyme 1A, Dcp1a ELISA KIT
ELI-26330m
Lifescience Market
96 Tests
EUR 1038
Human mRNA- decapping enzyme 1A, DCP1A ELISA KIT
ELI-47012h
Lifescience Market
96 Tests
EUR 988.8
Mouse mRNA-decapping enzyme 1B (DCP1B) ELISA Kit
abx509838-96tests
Abbexa
96 tests
EUR 687.5
Human mRNA-Decapping Enzyme 1B (DCP1B) ELISA Kit
abx386810-96tests
Abbexa
96 tests
EUR 687.5
Mouse mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9341841-10x96StripWells
MyBiosource
10x96-Strip-Wells
EUR 6725
Mouse mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9341841-48StripWells
MyBiosource
48-Strip-Wells
EUR 550
Mouse mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9341841-5x96StripWells
MyBiosource
5x96-Strip-Wells
EUR 3420
Mouse mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9341841-96StripWells
MyBiosource
96-Strip-Wells
EUR 765
Human mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9338025-10x96StripWells
MyBiosource
10x96-Strip-Wells
EUR 6725
Human mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9338025-48StripWells
MyBiosource
48-Strip-Wells
EUR 550
Human mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9338025-5x96StripWells
MyBiosource
5x96-Strip-Wells
EUR 3420
Human mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9338025-96StripWells
MyBiosource
96-Strip-Wells
EUR 765
Bovine mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9337109-10x96StripWells
MyBiosource
10x96-Strip-Wells
EUR 6725
Bovine mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9337109-48StripWells
MyBiosource
48-Strip-Wells
EUR 550
Bovine mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9337109-5x96StripWells
MyBiosource
5x96-Strip-Wells
EUR 3420
Bovine mRNA-decapping enzyme 1B, DCP1B ELISA Kit
MBS9337109-96StripWells
MyBiosource
96-Strip-Wells
EUR 765
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 405)
MBS6413675-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 405)
MBS6413675-5x01mL
MyBiosource
5x0.1mL
EUR 4120
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 490)
MBS6413676-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 490)
MBS6413676-5x01mL
MyBiosource
5x0.1mL
EUR 4120
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 550)
MBS6413677-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 550)
MBS6413677-5x01mL
MyBiosource
5x0.1mL
EUR 4120
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 650)
MBS6413678-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 650)
MBS6413678-5x01mL
MyBiosource
5x0.1mL
EUR 4120
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 750)
MBS6413679-01mL
MyBiosource
0.1mL
EUR 950
DCP1B (mRNA-Decapping Enzyme 1B, DCP1, hDcp1b) (MaxLight 750)
MBS6413679-5x01mL
MyBiosource
5x0.1mL
EUR 4120
Recombinant Bovine mRNA-decapping enzyme 1B (DCP1B) , partial
MBS1321205-INQUIRE
MyBiosource
INQUIRE
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Rat Scavenger mRNA- decapping enzyme DcpS, Dcps ELISA KIT
ELI-32404r
Lifescience Market
96 Tests
EUR 1063.2
Human Scavenger mRNA- decapping enzyme DcpS, DCPS ELISA KIT
ELI-08941h
Lifescience Market
96 Tests
EUR 988.8
Mouse Scavenger mRNA- decapping enzyme DcpS, Dcps ELISA KIT
ELI-48380m
Lifescience Market
96 Tests
EUR 1038
Bovine Scavenger mRNA- decapping enzyme DcpS, DCPS ELISA KIT
ELI-26524b
Lifescience Market
96 Tests
EUR 1113.6
Porcine Scavenger mRNA- decapping enzyme DcpS, DCPS ELISA KIT
ELI-07878p
Lifescience Market
96 Tests
EUR 1113.6
Recombinant Pongo abelii mRNA-decapping enzyme 1B (DCP1B), partial
MBS1288890-INQUIRE
MyBiosource
INQUIRE
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Human Decapping Enzyme 2 (DCP2) ELISA Kit
MBS9312948-10x96StripWells
MyBiosource
10x96-Strip-Wells
EUR 6725
Human Decapping Enzyme 2 (DCP2) ELISA Kit
MBS9312948-48StripWells
MyBiosource
48-Strip-Wells
EUR 550
Human Decapping Enzyme 2 (DCP2) ELISA Kit
MBS9312948-5x96StripWells
MyBiosource
5x96-Strip-Wells
EUR 3420
Human Decapping Enzyme 2 (DCP2) ELISA Kit
MBS9312948-96StripWells
MyBiosource
96-Strip-Wells
EUR 765
DCP2 (untagged)-Human DCP2 decapping enzyme homolog (S. cerevisiae) (DCP2)
SC100774
Origene Technologies GmbH
10 µg
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Dcp2 (untagged) - Mouse DCP2 decapping enzyme homolog (S. cerevisiae) (Dcp2), (10ug)
MC211089
Origene Technologies GmbH
10 µg
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DCP2 (GFP-tagged) - Human DCP2 decapping enzyme homolog (S. cerevisiae) (DCP2)
RG221165
Origene Technologies GmbH
10 µg
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DCP1A (untagged)-Human DCP1 decapping enzyme homolog A (S. cerevisiae) (DCP1A)
SC318001
Origene Technologies GmbH
10 µg
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DCP1A (untagged)-Human DCP1 decapping enzyme homolog A (S. cerevisiae) (DCP1A)
SC319488
Origene Technologies GmbH
10 µg
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Decapping Enzyme, Scavenger (DCPS) Antibody
abx029282-400ul
Abbexa
400 ul
EUR 627.6
Decapping Enzyme, Scavenger (DCPS) Antibody
20-abx125746
Abbexa
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20 ul
50 ul
100 ul
200 ul
Tubulin modifying enzymes as goal for the therapy of tau-related ailments
Within the mind of sufferers with Alzheimer’s illness (AD), the quantity and size of microtubules (MTs) are considerably and selectively diminished. MTs are concerned in a variety of mobile features, and defects of the microtubular system have emerged as a unifying speculation for the heterogeneous and variable medical shows of AD. ‘
MTs orchestrate their quite a few features by means of the spatiotemporal regulation of the binding of specialized microtubule-associated proteins (MAPs) and molecular motors. Covalent posttranslational modifications (PTMs) on the tubulin C-termini that protrude on the floor of MTs regulate the binding of those effectors.
In neurons, MAP tau is very considerable and its irregular dissociation from MTs within the axon, mobile mislocalization and hyperphosphorylation, are main occasions resulting in neuronal dying. Consequently, compounds concentrating on tau phosphorylation or aggregation are at present evaluated however their medical significance has not been demonstrated On this assessment, we focus on the rising hyperlink between tubulin PTMs and tau dysfunction. In neurons, excessive ranges of glutamylation and detyrosination profoundly impression the physicochemical properties on the floor of MTs.
Furthermore, in sufferers with early-onset progressive neurodegeneration, deleterious mutations in enzymes concerned in modifying MTs on the floor have just lately been recognized, underscoring the significance of this enzymatic equipment in neurology. We postulate that pharmacologically concentrating on the tubulin-modifying enzymes holds promise as therapeutic strategy for the therapy of neurodegenerative ailments.
Organoarsenicals inhibit bacterial peptidoglycan biosynthesis by concentrating on the important enzyme MurA
Trivalent organoarsenicals corresponding to methylarsenite (MAs(III)) are significantly extra poisonous than inorganic arsenate (As(V)) or arsenite (As(III)). In microbial communities MAs(III) reveals important antimicrobial exercise. Though MAs(III) and different organoarsenicals contribute to the worldwide arsenic biogeocycle, how they exert antibiotic-like properties is basically unknown. To determine attainable targets of MAs(III), a genomic library of the gram-negative bacterium,
Shewanellaputrefaciens 200, was expressed in Escherichia coli with choice for MAs(III) resistance. One clone contained the S. putrefaciensmurA gene (SpmurA), which catalyzes the primary dedicated step in peptidoglycan biosynthesis. Overexpression of SpmurA conferred MAs(III) resistance to E. coli.
Purified SpMurA was inhibited by MAs(III), phenylarsenite (PhAs(III)) or the phosphonate antibiotic fosfomycin however not by inorganic As(III). Fosfomycin inhibits MurA by binding to a conserved residue that corresponds to Cys117 in SpMurA. A C117D mutant was proof against fosfomycin however remained delicate to MAs(III), indicating that the 2 compounds have totally different mechanisms of motion. New inhibitors of peptidoglycan biosynthesis are extremely wanted as antimicrobial medication, and organoarsenicals characterize a new space for the event of novel compounds for combating the specter of antibiotic resistance.
ECE1 (Endothelin Converting Enzyme 1, ECE) (HRP)
MBS6414917-01mL
MyBiosource
0.1mL
EUR 950
ECE1 (Endothelin Converting Enzyme 1, ECE) (HRP)
MBS6414917-5x01mL
MyBiosource
5x0.1mL
EUR 4120
ECE1 (Endothelin Converting Enzyme 1, ECE) (FITC)
MBS6414916-01mL
MyBiosource
0.1mL
EUR 950
ECE1 (Endothelin Converting Enzyme 1, ECE) (FITC)
MBS6414916-5x01mL
MyBiosource
5x0.1mL
EUR 4120
ECE1 (Endothelin Converting Enzyme 1, ECE) (Biotin)
MBS6414915-01mL
MyBiosource
0.1mL
EUR 950
ECE1 (Endothelin Converting Enzyme 1, ECE) (Biotin)
MBS6414915-5x01mL
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5x0.1mL
EUR 4120
ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 405)
MBS6414918-01mL
MyBiosource
0.1mL
EUR 950
ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 405)
MBS6414918-5x01mL
MyBiosource
5x0.1mL
EUR 4120
ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 490)
MBS6414919-01mL
MyBiosource
0.1mL
EUR 950
ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 490)
MBS6414919-5x01mL
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5x0.1mL
EUR 4120
ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 550)
MBS6414920-01mL
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0.1mL
EUR 950
ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 550)
MBS6414920-5x01mL
MyBiosource
5x0.1mL
EUR 4120
ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 650)
MBS6414921-01mL
MyBiosource
0.1mL
EUR 950
ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 650)
MBS6414921-5x01mL
MyBiosource
5x0.1mL
EUR 4120
ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 750)
MBS6414922-01mL
MyBiosource
0.1mL
EUR 950
ECE1 (Endothelin Converting Enzyme 1, ECE) (MaxLight 750)
MBS6414922-5x01mL
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5x0.1mL
EUR 4120
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx033018-400l
Abbexa
400 µl
EUR 518.75
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx033018-400ul
Abbexa
400 ul
EUR 627.6
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx033018-80l
Abbexa
80 µl
EUR 281.25
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx033019-400l
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400 µl
EUR 518.75
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx033019-400ul
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400 ul
EUR 627.6
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx033019-80l
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80 µl
EUR 281.25
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx033020-400l
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400 µl
EUR 518.75
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx033020-400ul
Abbexa
400 ul
EUR 627.6
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx033020-80l
Abbexa
80 µl
EUR 281.25
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx004310-100l
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100 µl
EUR 475
Endothelin Converting Enzyme 1 (ECE1) Antibody
20-abx004310
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx004310-20l
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20 µl
EUR 200
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx004310-50l
Abbexa
50 µl
EUR 325
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx214580-100tests
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100 tests
EUR 350
Endothelin Converting Enzyme 1 (ECE1) Antibody
20-abx214580
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx214580-200tests
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200 tests
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx214580-20tests
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20 tests
EUR 250
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx103137-100l
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100 µl
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Endothelin Converting Enzyme 1 (ECE1) Antibody
20-abx103137
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx103137-1ml
Abbexa
1 ml
EUR 675
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx103137-200l
Abbexa
200 µl
EUR 312.5
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx103138-100l
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100 µl
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20-abx103138
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx103138-1ml
Abbexa
1 ml
EUR 687.5
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx103138-200l
Abbexa
200 µl
EUR 325
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx145201-100ug
Abbexa
100 ug
EUR 469.2
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx145201-1096tests
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10 × 96 tests
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx145201-596tests
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5 × 96 tests
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abx145201-96tests
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96 tests
EUR 337.5
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx130012-100l
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100 µl
EUR 262.5
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20-abx130012
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx130012-1ml
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1 ml
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx130012-200l
Abbexa
200 µl
EUR 337.5
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx320177-100l
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100 µl
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Endothelin Converting Enzyme 1 (ECE1) Antibody
20-abx320177
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx320177-50l
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50 µl
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Endothelin Converting Enzyme 1 (ECE1) Antibody
20-abx172239
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx172239-1ml
Abbexa
1 ml
EUR 712.5
Endothelin Converting Enzyme 1 (ECE1) Antibody
abx214643-100tests
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100 tests
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Endothelin Converting Enzyme 1 (ECE1) Antibody
20-abx214643
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abx214643-200tests
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200 tests
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Endothelin Converting Enzyme 1 (ECE1) Antibody
abx214643-20tests
Abbexa
20 tests
EUR 250
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2030000-001mg
MyBiosource
0.01mg
EUR 175
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2030000-005mg
MyBiosource
0.05mg
EUR 320
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2030000-01mg
MyBiosource
0.1mg
EUR 485
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2030000-02mg
MyBiosource
0.2mg
EUR 600
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2030000-05mg
MyBiosource
0.5mg
EUR 1135
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2009887-001mg
MyBiosource
0.01mg
EUR 175
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2009887-005mg
MyBiosource
0.05mg
EUR 310
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2009887-01mg
MyBiosource
0.1mg
EUR 470
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2009887-02mg
MyBiosource
0.2mg
EUR 575
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2009887-05mg
MyBiosource
0.5mg
EUR 1090
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2009889-001mg
MyBiosource
0.01mg
EUR 170
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2009889-005mg
MyBiosource
0.05mg
EUR 295
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2009889-01mg
MyBiosource
0.1mg
EUR 445
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2009889-02mg
MyBiosource
0.2mg
EUR 540
Recombinant Endothelin Converting Enzyme 1 (ECE1)
MBS2009889-05mg
MyBiosource
0.5mg
EUR 1025
Recombinant Endothelin Converting Enzyme 1 (ECE1)
RPA483Hu01
Cloud-Clone
10ug
EUR 168
Recombinant Endothelin Converting Enzyme 1 (ECE1)
4-RPA483Hu01
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1 mg
5 mg
Description: Recombinant Human Endothelin Converting Enzyme 1 expressed in: E.coli
Recombinant Endothelin Converting Enzyme 1 (ECE1)
RPA483Mu01
Cloud-Clone
10ug
EUR 180
Recombinant Endothelin Converting Enzyme 1 (ECE1)
4-RPA483Mu01
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Description: Recombinant Mouse Endothelin Converting Enzyme 1 expressed in: E.coli
Recombinant Endothelin Converting Enzyme 1 (ECE1)
RPA483Ra01
Cloud-Clone
10ug
EUR 188
Recombinant Endothelin Converting Enzyme 1 (ECE1)
4-RPA483Ra01
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Description: Recombinant Rat Endothelin Converting Enzyme 1 expressed in: E.coli
Recombinant Endothelin Converting Enzyme 1 (ECE1)
RPU41274-100ug
Biomatik Corporation
100ug
EUR 554.4
Recombinant Endothelin Converting Enzyme 1 (ECE1)
RPU54158-100ug
Biomatik Corporation
100ug
EUR 578.6
Rat Endothelin Converting Enzyme 1 (ECE1) Protein
20-abx168533
Abbexa
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10 ug
50 ug
100 ug
200 ug
1 mg
Rat Endothelin Converting Enzyme 1 (ECE1) Protein
abx168533-1ml
Abbexa
1 ml
EUR 237.5
Human Endothelin Converting Enzyme 1 (ECE1) Protein
abx066416-100g
Abbexa
100 µg
EUR 550
Human Endothelin Converting Enzyme 1 (ECE1) Protein
20-abx066416
Abbexa
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10 ug
50 ug
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1 mg
Human Endothelin Converting Enzyme 1 (ECE1) Protein
abx066416-10g
Abbexa
10 µg
EUR 212.5
Human Endothelin Converting Enzyme 1 (ECE1) Protein
abx066416-50g
Abbexa
50 µg
EUR 387.5
Mouse Endothelin Converting Enzyme 1 (ECE1) Protein
abx066417-100g
Abbexa
100 µg
EUR 587.5
Mouse Endothelin Converting Enzyme 1 (ECE1) Protein
20-abx066417
Abbexa
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Mouse Endothelin Converting Enzyme 1 (ECE1) Protein
abx066417-10g
Abbexa
10 µg
EUR 225
Mouse Endothelin Converting Enzyme 1 (ECE1) Protein
abx066417-50g
Abbexa
50 µg
EUR 400
ECE-1, Recombinant, Mouse (Endothelin Converting Enzyme-1)
MBS638185-001mg
MyBiosource
0.01mg
EUR 875
ECE-1, Recombinant, Mouse (Endothelin Converting Enzyme-1)
MBS638185-5x001mg
MyBiosource
5x0.01mg
EUR 3720
Cow Endothelin Converting Enzyme 1 (ECE1) ELISA Kit
abx521037-96tests
Abbexa
96 tests
EUR 687.5
Rat Endothelin Converting Enzyme 1 (ECE1) ELISA Kit
abx521040-96tests
Abbexa
96 tests
EUR 687.5
Pig Endothelin Converting Enzyme 1 (ECE1) ELISA Kit
abx361861-96tests
Abbexa
96 tests
EUR 990
Rat Endothelin Converting Enzyme 1 (ECE1) ELISA Kit
MBS3808174-10x96StripWells
MyBiosource
10x96-Strip-Wells
EUR 6725