In vivo MRS measurement of 2-hydroxyglutarate in patient-derived IDH-mutant xenograft mouse models versus glioma patients.

To produce a preclinical model isocitrate dehydrogenase (IDH) of the mutant glioma glioma patients and devise methods to test the compatibility MRS 2-hydroxyglutarate production (2HG) between preclinical models and patients.

Five patient-derived xenograft (PDX) rat glioma generated from two patients with IDH1 R132H mutation. A sequence PRESS adjusted at 9.4 T, with a phantom computer simulation and analysis, to improve the detection of 2HG in mice. 2HG and other metabolites in rats was measured using MRS optimized PDX at 9.4 T and compared with 3 T MRS measurements of metabolites in parent-tumor patients.

LCModel spectral fitting is done by using the home as a spectrum. metabolite levels were measured with reference to water.The PRESS TE optimized to 96 ms, which 2HG 2.25 ppm signal is narrow and overturned, causing a strict separation of resonance 2HG of adjacent signals from other metabolites. MRS optimized supplied precise detection 2HG in mice compared to short-TE MRS at 9.4 T. estimate of 2HG in PDX rats in good agreement with measurements of 2HG in 2HG production patients.The similarity between the model and parent PDX-tumor patients showed that the tumor PDX IDH maintain metabolic fingerprint parents and can serve as a preclinical model to improve our understanding of IDH mutations associated metabolic reprogramming.

Mutations start contributing to the development of cancer is sometimes present in premalignant cells. Is this mutation targeting therapy can eradicate premalignant cells is unclear. Acute myeloid leukemia (AML) is an interesting system to investigate the effects of preventive treatment for the disease is often preceded by premalignant state (clonal hematopoiesis or myelodysplastic syndromes).

In Npm1c / Dnmt3a mutant knock-in mice, the model of development of AML, leukemia preceded by an extended period of myeloid progenitor cell proliferation and self-renewal. We discovered that this self-renewal can be reversed with oral administration of small molecule (VTP-50 469) that targets MLL1-Menin chromatin complexes. The results of the preclinical support the hypothesis that high-risk individuals develop AML may benefit from targeted epigenetic therapy in the prevention setting.

The acquisition of genetic mutations in a group A streptococcus at the site of infection and subsequent systemic spread of the mutant with a lethal mutation in a mouse model of streptococcal toxic shock syndrome.

Streptococcal toxic shock syndrome (STSS) is caused mainly by Streptococcus pyogenes (Group A Streptococcus, GAS), and has a mortality rate of 25%. Mutations in CsrRS and RopB, which suppresses the transcription of many virulence factors, was recently found in clinical isolates from STSS patients, but do not fully understand when and where GAS acquire a mutation in the host.

To resolve this question, we use our mouse models of human STSS GAS strains to recover from the injection sites, spleen and blood of mice dying with STSS-like symptoms, and analyzing sequence covR / covS genes and genes encoding ropB CsrRS and RopB. Fifteen of the twenty mice were inoculated transdermally into the muscle with GAS organisms become moribund with STSS-like symptoms after more than 20 days after the inoculation.

Tissue cDNA, First Strand, Mouse Adult Normal, Liver, BioGenomics
MBS651975-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Mouse Adult Normal, Liver, BioGenomics
MBS651975-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Canine Adult Normal, Liver, BioGenomics
MBS652364-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Canine Adult Normal, Liver, BioGenomics
MBS652364-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Liver, Left Lobe, BioGenomics
MBS652382-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Liver, Left Lobe, BioGenomics
MBS652382-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Liver, Right Lobe, BioGenomics
MBS652391-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Liver, Right Lobe, BioGenomics
MBS652391-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Liver, BioGenomics
MBS652077-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Liver, BioGenomics
MBS652077-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, BioGenomics
MBS652120-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, BioGenomics
MBS652120-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Liver, Left Lobe, BioGenomics
MBS652400-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Liver, Left Lobe, BioGenomics
MBS652400-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Liver, Right Lobe, BioGenomics
MBS652420-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Liver, Right Lobe, BioGenomics
MBS652420-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Skin, BioGenomics
MBS651946-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Skin, BioGenomics
MBS651946-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Lung, BioGenomics
MBS652185-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Lung, BioGenomics
MBS652185-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Heart, BioGenomics
MBS652300-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Heart, BioGenomics
MBS652300-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Colon, BioGenomics
MBS652410-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Colon, BioGenomics
MBS652410-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Brain, BioGenomics
MBS652047-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Brain, BioGenomics
MBS652047-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Theca, BioGenomics
MBS652079-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Theca, BioGenomics
MBS652079-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Tonsil, BioGenomics
MBS652456-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Tonsil, BioGenomics
MBS652456-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Tongue, BioGenomics
MBS652491-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Tongue, BioGenomics
MBS652491-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Throat, BioGenomics
MBS652534-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Throat, BioGenomics
MBS652534-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Rectum, BioGenomics
MBS652577-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Rectum, BioGenomics
MBS652577-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Uterus, BioGenomics
MBS651999-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Uterus, BioGenomics
MBS651999-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Testis, BioGenomics
MBS652030-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Testis, BioGenomics
MBS652030-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Breast, BioGenomics
MBS652083-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Breast, BioGenomics
MBS652083-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Spleen, BioGenomics
MBS652259-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Spleen, BioGenomics
MBS652259-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Kidney, BioGenomics
MBS652261-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Kidney, BioGenomics
MBS652261-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, Right Lobe, BioGenomics
MBS652345-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, Right Lobe, BioGenomics
MBS652345-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, Left Lobe, BioGenomics
MBS652555-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, Left Lobe, BioGenomics
MBS652555-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Thyroid, BioGenomics
MBS652574-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Thyroid, BioGenomics
MBS652574-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Stomach, BioGenomics
MBS651867-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Stomach, BioGenomics
MBS651867-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Bladder, BioGenomics
MBS651871-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Bladder, BioGenomics
MBS651871-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Adrenal, BioGenomics
MBS651970-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Adrenal, BioGenomics
MBS651970-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Adipose, BioGenomics
MBS652135-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Adipose, BioGenomics
MBS652135-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Placenta, BioGenomics
MBS652328-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Placenta, BioGenomics
MBS652328-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Prostate, BioGenomics
MBS652399-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Prostate, BioGenomics
MBS652399-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Duodenum, BioGenomics
MBS651927-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Duodenum, BioGenomics
MBS651927-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Pancreas, BioGenomics
MBS652189-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Pancreas, BioGenomics
MBS652189-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Esophagus, BioGenomics
MBS652478-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Esophagus, BioGenomics
MBS652478-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Eye, Whole, BioGenomics
MBS652434-10Tests	MyBiosource	10Tests	EUR 750

Tissue cDNA, First Strand, Human Adult Normal, Eye, Whole, BioGenomics
MBS652434-5x10Tests	MyBiosource	5x10Tests	EUR 3145

Tissue cDNA, First Strand, Human Adult Normal, Brain, Pons, BioGenomics
MBS652299-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Brain, Pons, BioGenomics
MBS652299-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Lymph node, BioGenomics
MBS652078-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Lymph node, BioGenomics
MBS652078-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Bone Marrow, BioGenomics
MBS652385-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Bone Marrow, BioGenomics
MBS652385-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Spinal cord, BioGenomics
MBS652436-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Spinal cord, BioGenomics
MBS652436-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Lung, Trachea, BioGenomics
MBS652253-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Lung, Trachea, BioGenomics
MBS652253-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Cardia, BioGenomics
MBS652430-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Cardia, BioGenomics
MBS652430-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Corpus, BioGenomics
MBS652435-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Corpus, BioGenomics
MBS652435-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Fundus, BioGenomics
MBS652490-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Fundus, BioGenomics
MBS652490-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Colon sigmoid, BioGenomics
MBS652527-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Colon sigmoid, BioGenomics
MBS652527-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Corpus, BioGenomics
MBS652550-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Corpus, BioGenomics
MBS652550-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Fallopian Tube, BioGenomics
MBS652556-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Fallopian Tube, BioGenomics
MBS652556-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Brain, Thalamus, BioGenomics
MBS652560-10Tests	MyBiosource	10Tests	EUR 495

Tissue cDNA, First Strand, Human Adult Normal, Brain, Thalamus, BioGenomics
MBS652560-40Tests	MyBiosource	40Tests	EUR 775

Tissue cDNA, First Strand, Human Adult Normal, Brain, Thalamus, BioGenomics
MBS652560-5x40Tests	MyBiosource	5x40Tests	EUR 3270

Tissue cDNA, First Strand, Human Adult Normal, Brain, Amygdala, BioGenomics
MBS652587-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Brain, Amygdala, BioGenomics
MBS652587-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Cervix, BioGenomics
MBS651890-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Cervix, BioGenomics
MBS651890-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Fundus, BioGenomics
MBS651912-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Fundus, BioGenomics
MBS651912-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Salivary gland, BioGenomics
MBS652022-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Salivary gland, BioGenomics
MBS652022-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Pylorus, BioGenomics
MBS652462-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Pylorus, BioGenomics
MBS652462-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Colon transverse, BioGenomics
MBS652512-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Colon transverse, BioGenomics
MBS652512-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Skeletal Muscle, BioGenomics
MBS652565-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Skeletal Muscle, BioGenomics
MBS652565-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Small intestine, BioGenomics
MBS652588-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Small intestine, BioGenomics
MBS652588-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Brain, Pituitary, BioGenomics
MBS651901-10Tests	MyBiosource	10Tests	EUR 550

Tissue cDNA, First Strand, Human Adult Normal, Brain, Pituitary, BioGenomics
MBS651901-5x10Tests	MyBiosource	5x10Tests	EUR 2255

Tissue cDNA, First Strand, Human Adult Normal, Colon descending, BioGenomics
MBS652112-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Colon descending, BioGenomics
MBS652112-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Colon ascending, BioGenomics
MBS652290-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Colon ascending, BioGenomics
MBS652290-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Lung, BioGenomics
MBS652470-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Lung, BioGenomics
MBS652470-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Colon, BioGenomics
MBS652432-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Rat Adult Normal, Colon, BioGenomics
MBS652432-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Rat Adult Normal, Brain, BioGenomics
MBS651977-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Brain, BioGenomics
MBS651977-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Heart, BioGenomics
MBS651984-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Heart, BioGenomics
MBS651984-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Brain, Hippocampus, BioGenomics
MBS651929-10Reactions	MyBiosource	10Reactions	EUR 550

Tissue cDNA, First Strand, Human Adult Normal, Brain, Hippocampus, BioGenomics
MBS651929-5x10Reactions	MyBiosource	5x10Reactions	EUR 2255

Tissue cDNA, First Strand, Rat Adult Normal, Spleen, BioGenomics
MBS652466-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Spleen, BioGenomics
MBS652466-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Testis, BioGenomics
MBS652483-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Testis, BioGenomics
MBS652483-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Mouse Adult Normal, Lung, BioGenomics
MBS652000-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Mouse Adult Normal, Lung, BioGenomics
MBS652000-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Rectum, BioGenomics
MBS652009-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Rat Adult Normal, Rectum, BioGenomics
MBS652009-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Rat Adult Normal, Kidney, BioGenomics
MBS652090-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Kidney, BioGenomics
MBS652090-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Mouse Adult Normal, Colon, BioGenomics
MBS652314-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Mouse Adult Normal, Colon, BioGenomics
MBS652314-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Rat Adult Normal, Stomach, BioGenomics
MBS652326-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Stomach, BioGenomics
MBS652326-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Mouse Adult Normal, Heart, BioGenomics
MBS652497-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Mouse Adult Normal, Heart, BioGenomics
MBS652497-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Mouse Adult Normal, Brain, BioGenomics
MBS651994-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Mouse Adult Normal, Brain, BioGenomics
MBS651994-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Canine Adult Normal, Lung, BioGenomics
MBS652012-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Canine Adult Normal, Lung, BioGenomics
MBS652012-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Bladder, BioGenomics
MBS652086-40Tests	MyBiosource	40Tests	EUR 680

We found that all strains of GAS are propagated recovered from blood and spleen of mice dying have a good mutation in a gene or genes covR covS. Site mutations in the GAS strains recovered from blood and spleen identical in each mouse, while strains recovered from muscle strains including a mixture of disseminated, other mutant strains and the parent strain.