Micturition defects and altered bladder function in the klotho mutant mouse model of aging

Introduction and objectives: Symptoms associated with detrusor underactivity (DU) or an underactive bladder (UAB) can greatly affect a person’s quality of life and growing old is a major etiologic factor DU and UAB. Klotho gene has been associated with suppression several phenotypes of aging, and there is a moderate klotho expression in the bladder. Considering this, we hypothesized that klotho gene involved in the regulation of bladder function. Thus, we examined the genetic model of premature aging rodents with hypomorphic klotho expression to changes in bladder function.

Methods: Klotho mutant mice designated as a preclinical model of aging. Men and women have urinary klotho mice were measured at weeks 4, 6, and 8 through metabolic cages and test place void. Histology is rated at 4, 6, and 8 weeks. Lastly, the contraction of the bladder was assessed using bladder tissue bath lines. All the animals are gender- and age-matched wild-type littermates for analysis.

Result: the Void and bladder contraction test klotho mutant mice revealed that, similar to other aging models, has risen to cancel the frequency and decreased urinary volume per micturition event. In vitro contractile response to electrical stimulation is weaker and subtypes of muscarinic receptor expression is reduced in the mutant mice klotho bladder. These data suggest that bladder klotho mutant mice have impaired bladder function.

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Lung, BioGenomics
MBS652069-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Lung, BioGenomics
MBS652069-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Tongue, BioGenomics
MBS651940-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Tongue, BioGenomics
MBS651940-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Ureter, BioGenomics
MBS651998-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Ureter, BioGenomics
MBS651998-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Heart, BioGenomics
MBS652056-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Heart, BioGenomics
MBS652056-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, BioGenomics
MBS652120-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, BioGenomics
MBS652120-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Throat, BioGenomics
MBS652160-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Throat, BioGenomics
MBS652160-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Colon, BioGenomics
MBS652183-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Colon, BioGenomics
MBS652183-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Tonsil, BioGenomics
MBS652198-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Tonsil, BioGenomics
MBS652198-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Testis, BioGenomics
MBS652233-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Testis, BioGenomics
MBS652233-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, BioGenomics
MBS652286-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, BioGenomics
MBS652286-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Thymus, BioGenomics
MBS652377-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Thymus, BioGenomics
MBS652377-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Spleen, BioGenomics
MBS652395-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Spleen, BioGenomics
MBS652395-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Kidney, BioGenomics
MBS652401-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Kidney, BioGenomics
MBS652401-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Uterus, BioGenomics
MBS652498-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Uterus, BioGenomics
MBS652498-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Cecum, BioGenomics
MBS652528-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Cecum, BioGenomics
MBS652528-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Penis, BioGenomics
MBS652540-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Penis, BioGenomics
MBS652540-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Vagina, BioGenomics
MBS652590-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Vagina, BioGenomics
MBS652590-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Thyroid, BioGenomics
MBS652020-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Thyroid, BioGenomics
MBS652020-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Prostate, BioGenomics
MBS652186-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Prostate, BioGenomics
MBS652186-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Trachea, BioGenomics
MBS652209-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Trachea, BioGenomics
MBS652209-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Pancreas, BioGenomics
MBS652224-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Pancreas, BioGenomics
MBS652224-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Stomach, BioGenomics
MBS652274-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Stomach, BioGenomics
MBS652274-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Parotid, BioGenomics
MBS652322-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Parotid, BioGenomics
MBS652322-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Adrenal, BioGenomics
MBS652357-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Adrenal, BioGenomics
MBS652357-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Bladder, BioGenomics
MBS652419-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Bladder, BioGenomics
MBS652419-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Adipose, BioGenomics
MBS652422-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Adipose, BioGenomics
MBS652422-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Appendix, BioGenomics
MBS652546-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Appendix, BioGenomics
MBS652546-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Esophagus, BioGenomics
MBS651931-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Esophagus, BioGenomics
MBS651931-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Diaphragm, BioGenomics
MBS652119-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Diaphragm, BioGenomics
MBS652119-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Epididymis, BioGenomics
MBS652284-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Epididymis, BioGenomics
MBS652284-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Whole Eye, BioGenomics
MBS651925-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Whole Eye, BioGenomics
MBS651925-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Gallbladder, BioGenomics
MBS652403-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Gallbladder, BioGenomics
MBS652403-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Spinal Cord, BioGenomics
MBS652180-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Spinal Cord, BioGenomics
MBS652180-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Pons, BioGenomics
MBS652327-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Pons, BioGenomics
MBS652327-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Uterus, Cervis, BioGenomics
MBS651910-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Uterus, Cervis, BioGenomics
MBS651910-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Choriod, BioGenomics
MBS651944-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Choriod, BioGenomics
MBS651944-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Insula, BioGenomics
MBS652352-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Insula, BioGenomics
MBS652352-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Amygdala, BioGenomics
MBS651953-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Amygdala, BioGenomics
MBS651953-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Small Intestine, BioGenomics
MBS652108-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Small Intestine, BioGenomics
MBS652108-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Olfactory, BioGenomics
MBS652306-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Olfactory, BioGenomics
MBS652306-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Pituitary, BioGenomics
MBS652429-40Tests	MyBiosource	40Tests	EUR 970

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Pituitary, BioGenomics
MBS652429-5x40Tests	MyBiosource	5x40Tests	EUR 4150

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Skeletal Muscle, BioGenomics
MBS652438-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Skeletal Muscle, BioGenomics
MBS652438-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Cerebellum, BioGenomics
MBS652196-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Cerebellum, BioGenomics
MBS652196-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Hippocampus, BioGenomics
MBS652355-40Tests	MyBiosource	40Tests	EUR 970

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Hippocampus, BioGenomics
MBS652355-5x40Tests	MyBiosource	5x40Tests	EUR 4150

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Heart, Pericardium, BioGenomics
MBS652427-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Heart, Pericardium, BioGenomics
MBS652427-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, Right Lobe, BioGenomics
MBS652345-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, Right Lobe, BioGenomics
MBS652345-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, Left Lobe, BioGenomics
MBS652555-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Liver, Left Lobe, BioGenomics
MBS652555-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Diencephalon, BioGenomics
MBS652158-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Diencephalon, BioGenomics
MBS652158-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Frontal Lobe, BioGenomics
MBS652298-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Frontal Lobe, BioGenomics
MBS652298-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Pineal Gland, BioGenomics
MBS652308-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Pineal Gland, BioGenomics
MBS652308-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Temporal Lobe, BioGenomics
MBS651990-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Temporal Lobe, BioGenomics
MBS651990-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Parietal Lobe, BioGenomics
MBS652252-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Parietal Lobe, BioGenomics
MBS652252-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Occipital Lobe, BioGenomics
MBS652467-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Occipital Lobe, BioGenomics
MBS652467-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Small Intestine, Ileum, BioGenomics
MBS651996-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Small Intestine, Ileum, BioGenomics
MBS651996-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Cerebral Cortex, BioGenomics
MBS652139-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Cerebral Cortex, BioGenomics
MBS652139-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Precentral Gyrus, BioGenomics
MBS652258-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Precentral Gyrus, BioGenomics
MBS652258-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Corpus Callosum, BioGenomics
MBS652500-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Corpus Callosum, BioGenomics
MBS652500-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Small Intestine, Jejunum, BioGenomics
MBS652048-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Small Intestine, Jejunum, BioGenomics
MBS652048-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Medulla Oblongata, BioGenomics
MBS652245-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Medulla Oblongata, BioGenomics
MBS652245-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Postcentral Gyrus, BioGenomics
MBS652273-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Brain, Postcentral Gyrus, BioGenomics
MBS652273-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Small Intestine, Duodenum, BioGenomics
MBS652539-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Small Intestine, Duodenum, BioGenomics
MBS652539-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Rectum, BioGenomics
MBS652392-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Rectum, BioGenomics
MBS652392-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Rectum, BioGenomics
MBS652009-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Rat Adult Normal, Rectum, BioGenomics
MBS652009-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Mouse Adult Normal, Rectum, BioGenomics
MBS652184-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Mouse Adult Normal, Rectum, BioGenomics
MBS652184-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Human Adult Normal, Rectum, BioGenomics
MBS652577-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Rectum, BioGenomics
MBS652577-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Canine Adult Normal, Rectum, BioGenomics
MBS652161-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Canine Adult Normal, Rectum, BioGenomics
MBS652161-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Skin, BioGenomics
MBS652159-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Skin, BioGenomics
MBS652159-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Lung, BioGenomics
MBS652307-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Lung, BioGenomics
MBS652307-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Vagina, BioGenomics
MBS651864-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Vagina, BioGenomics
MBS651864-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Tonsil, BioGenomics
MBS651891-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Tonsil, BioGenomics
MBS651891-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Brain, BioGenomics
MBS651963-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Brain, BioGenomics
MBS651963-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Colon, BioGenomics
MBS652007-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Colon, BioGenomics
MBS652007-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Uterus, BioGenomics
MBS652015-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Uterus, BioGenomics
MBS652015-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Spleen, BioGenomics
MBS652031-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Spleen, BioGenomics
MBS652031-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Thymus, BioGenomics
MBS652057-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Thymus, BioGenomics
MBS652057-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Liver, BioGenomics
MBS652077-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Liver, BioGenomics
MBS652077-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Throat, BioGenomics
MBS652166-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Throat, BioGenomics
MBS652166-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Penis, BioGenomics
MBS652168-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Penis, BioGenomics
MBS652168-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Cecum, BioGenomics
MBS652246-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Cecum, BioGenomics
MBS652246-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Testis, BioGenomics
MBS652339-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Testis, BioGenomics
MBS652339-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Heart, BioGenomics
MBS652369-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Heart, BioGenomics
MBS652369-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Ureter, BioGenomics
MBS652433-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Ureter, BioGenomics
MBS652433-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Conclusion: Klotho mutant mice recapitulate many of the characteristics of a dysfunctional bladder older, including bladder function changes. Given the short timeframe for bladder dysfunction and robustness of the model, this model will provide new insight to encourage the study of aging bladder.

Landscape metabolism of Genetically Engineered Mutant Rat Glioma Model IDH1

Understanding metabolic reprogramming aggressive brain tumor has potential applications for the treatment and imaging biomarkers. However, little is known about the nutritional requirements of isocitrate dehydrogenase 1 (IDH1) mutant glioma.

The IDH1 mutation involve acquisitions neomorphic enzymatic activity that produces D-2-hydroxyglutarate of α-ketoglutarate. In order to gain insight into this metabolism of malignant brain tumor, we performed metabolic profiling orthotopic tumor and contralateral area for glioma IDH1 mutant mouse model; as well as to test the use of glucose and glutamine in supplying major metabolic pathways such as glycolysis and the tricarboxylic acid (TCA).

We also revealed that the main substrate 2-hydroxyglutarate is glutamine in this model, and how the re-routing of this destructive utilization in the TCA. Our 13C tracing analysis, along with hyperpolarized magnetic resonance experiments, expressing the same glycolytic pathway active in both areas (tumor and contralateral) of the brain. Therefore, we describe the reprogramming of the central carbon metabolism associated with IDH1 mutations in genetically engineered mouse models that reflect tumor biology encountered in patients with glioma.

Bone is one of the sites most frequently in lung cancer metastatic non-small cell (NSCLC). Osimertinib, with and without bevacizumab (BV), has been studied in patients with advanced NSCLC. However, the efficacy of drugs on bone metastases of NSCLC has not been studied. H1975 human NSCLC cell lines, expressing red fluorescent protein (H1975-RFP), it orthotopically injected into the tibia of nude mice. established mouse models were randomized into four treatment groups of nine rats: Control; BV only; osimertinib only; osimertinib and BV combination.