The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects

Chronic otitis media (OM) is the most common cause of hearing loss worldwide, but the underlying genetic and molecular pathology are poorly understood. Jeff mutant mouse is a mouse model for OM identified a single gene on the screen deaf as part of an ENU mutagenesis program at MRC Harwell. Jeff brings a missense mutation in the gene Fbxo11. Jeff heterozygous (Fbxo11 Jf / +) develop chronic OM at weaning and have reduced hearing.

Homozygous (Fbxo11 Jf / Jf) display perinatal lethal for the development of epithelial abnormality. In order to investigate the role FBXO11 and type of mutation responsible for the phenotype of mice Jeff, knock-out mouse models are created and compared to Jeff. Surprisingly, heterozygous knock-out (Fbxo11 tm2b / +) showed milder phenotype: they did not display any auditory deficits, and only some of them have thickened epithelial lining of the middle ear without fluid in the ear. In addition, the knock-out embryos homozygous (Fbxo11 tm2b / tm2b), as well as compound heterozygotes (Fbxo11 tm2b / Jf) show only mild abnormalities compared with homozygous Jeff (Fbxo11 Jf / Jf).

Interestingly, three days after inoculation intranasally of Fbxo11 tm2b / + mice with non-typeable Haemophilus influenzae (NTHI) proportion of them have been inflamed mucosa of the middle ear and accumulation of fluid in the ear indicates that Fbxo11 knock-out mice tend to NTHI induced inflammation of the middle ear. In conclusion, the finding that the mutant phenotype Jeff is much more severe than the knock-out show that a mutation in the manifest Jeff gain-of-function and loss-of-function effects on both embryonic and adult stages.

Congenital heart disease (CHD) affects nearly one percent of all live births. Despite advances in diagnostic and reparative surgery, causes and mechanisms of CHD is still mainly unknown. Extracellular matrix plays a major role in cell communication, function, and differentiation, and therefore may play a role in disease development and pathophysiology.

Cell adhesion and gap junction proteins, such as integrins and connexins, are also important for mobile communication and behavior, and can interact directly (integrins) or indirectly (connexins) with the extracellular matrix. In this work, we explore the gaps in the spatial pattern of expression and extracellular matrix, adhesion and gap junction protein between wild-type and Nkx2-5 + / RG mutant mice.

Nicotinamide riboside supplementation corrects deficits in oxytocin, socialization and anxiety of CD157 mutants in a mouse model of autism spectrum disorder

Oxytocin (OT) is an important molecule for social recognition and memory in social and emotional mediate behavior. In addition, PL act as a factor of anxiolytic and released during stress. Based on the activity of the enzyme that produces CD38 as calcium-mobilizing second messenger cyclic ADP-ribose (cADPR), CD157, CD38 sister protein, has been considered as candidate mediators for the production and release of OT and social engagement and anti-anxiety function.

However, the limited expression of CD157 in the adult rat brain undermines the trust participants molecule CD157 is authentic and / or followed up in social behavior OT-dependent. Here, we show that CD157 knockout mice had lower levels of circulating PL in the cerebrospinal fluid, which can be corrected by oral administration of nicotinamide riboside, vitamin precursor of nicotinamide adenine newfound dinucleotide (NAD).

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Cardia, BioGenomics
MBS652430-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Cardia, BioGenomics
MBS652430-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Corpus, BioGenomics
MBS652550-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Corpus, BioGenomics
MBS652550-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Fundus, BioGenomics
MBS651912-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Fundus, BioGenomics
MBS651912-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Mouse Adult Normal, Stomach, BioGenomics
MBS651892-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Mouse Adult Normal, Stomach, BioGenomics
MBS651892-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Canine Adult Normal, Stomach, BioGenomics
MBS652578-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Canine Adult Normal, Stomach, BioGenomics
MBS652578-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Pylorus, BioGenomics
MBS652462-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Stomach, Pylorus, BioGenomics
MBS652462-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Stomach, BioGenomics
MBS652520-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Stomach, BioGenomics
MBS652520-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Stomach, BioGenomics
MBS652274-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Monkey (Cynomolgus) Adult Normal, Stomach, BioGenomics
MBS652274-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Stomach, Cardia, BioGenomics
MBS652317-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Stomach, Cardia, BioGenomics
MBS652317-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Stomach, Pylorus, BioGenomics
MBS652402-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Stomach, Pylorus, BioGenomics
MBS652402-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Stomach, Corpus, BioGenomics
MBS651921-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Stomach, Corpus, BioGenomics
MBS651921-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Stomach, Fundus, BioGenomics
MBS652188-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Monkey (Rhesus) Adult Normal, Stomach, Fundus, BioGenomics
MBS652188-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Human Diseased (Adult), Diabetes, Stomach, BioGenomics
MBS652568-40Tests	MyBiosource	40Tests	EUR 995

Tissue cDNA, First Strand, Human Diseased (Adult), Diabetes, Stomach, BioGenomics
MBS652568-5x40Tests	MyBiosource	5x40Tests	EUR 4250

Tissue cDNA, First Strand, Human Adult Normal, Skin, BioGenomics
MBS651946-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Skin, BioGenomics
MBS651946-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Lung, BioGenomics
MBS652185-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Lung, BioGenomics
MBS652185-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Heart, BioGenomics
MBS652300-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Heart, BioGenomics
MBS652300-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Colon, BioGenomics
MBS652410-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Colon, BioGenomics
MBS652410-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Liver, BioGenomics
MBS651906-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Liver, BioGenomics
MBS651906-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Brain, BioGenomics
MBS652047-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Brain, BioGenomics
MBS652047-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Theca, BioGenomics
MBS652079-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Theca, BioGenomics
MBS652079-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Tonsil, BioGenomics
MBS652456-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Tonsil, BioGenomics
MBS652456-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Tongue, BioGenomics
MBS652491-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Tongue, BioGenomics
MBS652491-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Throat, BioGenomics
MBS652534-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Throat, BioGenomics
MBS652534-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Rectum, BioGenomics
MBS652577-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Rectum, BioGenomics
MBS652577-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Uterus, BioGenomics
MBS651999-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Uterus, BioGenomics
MBS651999-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Testis, BioGenomics
MBS652030-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Testis, BioGenomics
MBS652030-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Breast, BioGenomics
MBS652083-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Breast, BioGenomics
MBS652083-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Spleen, BioGenomics
MBS652259-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Spleen, BioGenomics
MBS652259-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Kidney, BioGenomics
MBS652261-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Kidney, BioGenomics
MBS652261-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Thyroid, BioGenomics
MBS652574-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Thyroid, BioGenomics
MBS652574-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Bladder, BioGenomics
MBS651871-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Bladder, BioGenomics
MBS651871-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Adrenal, BioGenomics
MBS651970-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Adrenal, BioGenomics
MBS651970-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Adipose, BioGenomics
MBS652135-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Adipose, BioGenomics
MBS652135-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Placenta, BioGenomics
MBS652328-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Placenta, BioGenomics
MBS652328-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Prostate, BioGenomics
MBS652399-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Prostate, BioGenomics
MBS652399-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Duodenum, BioGenomics
MBS651927-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Duodenum, BioGenomics
MBS651927-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Pancreas, BioGenomics
MBS652189-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Pancreas, BioGenomics
MBS652189-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Esophagus, BioGenomics
MBS652478-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Esophagus, BioGenomics
MBS652478-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Eye, Whole, BioGenomics
MBS652434-10Tests	MyBiosource	10Tests	EUR 750

Tissue cDNA, First Strand, Human Adult Normal, Eye, Whole, BioGenomics
MBS652434-5x10Tests	MyBiosource	5x10Tests	EUR 3145

Tissue cDNA, First Strand, Human Adult Normal, Brain, Pons, BioGenomics
MBS652299-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Brain, Pons, BioGenomics
MBS652299-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Lymph node, BioGenomics
MBS652078-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Lymph node, BioGenomics
MBS652078-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Bone Marrow, BioGenomics
MBS652385-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Bone Marrow, BioGenomics
MBS652385-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Spinal cord, BioGenomics
MBS652436-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Spinal cord, BioGenomics
MBS652436-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Lung, Trachea, BioGenomics
MBS652253-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Lung, Trachea, BioGenomics
MBS652253-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Corpus, BioGenomics
MBS652435-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Corpus, BioGenomics
MBS652435-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Fundus, BioGenomics
MBS652490-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Fundus, BioGenomics
MBS652490-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Colon sigmoid, BioGenomics
MBS652527-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Colon sigmoid, BioGenomics
MBS652527-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Fallopian Tube, BioGenomics
MBS652556-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Fallopian Tube, BioGenomics
MBS652556-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Brain, Thalamus, BioGenomics
MBS652560-10Tests	MyBiosource	10Tests	EUR 495

Tissue cDNA, First Strand, Human Adult Normal, Brain, Thalamus, BioGenomics
MBS652560-40Tests	MyBiosource	40Tests	EUR 775

Tissue cDNA, First Strand, Human Adult Normal, Brain, Thalamus, BioGenomics
MBS652560-5x40Tests	MyBiosource	5x40Tests	EUR 3270

Tissue cDNA, First Strand, Human Adult Normal, Brain, Amygdala, BioGenomics
MBS652587-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Brain, Amygdala, BioGenomics
MBS652587-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Cervix, BioGenomics
MBS651890-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Uterus, Cervix, BioGenomics
MBS651890-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Salivary gland, BioGenomics
MBS652022-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Salivary gland, BioGenomics
MBS652022-5x10Tests	MyBiosource	5x10Tests	EUR 2215

Tissue cDNA, First Strand, Human Adult Normal, Colon transverse, BioGenomics
MBS652512-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Colon transverse, BioGenomics
MBS652512-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Skeletal Muscle, BioGenomics
MBS652565-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Skeletal Muscle, BioGenomics
MBS652565-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Small intestine, BioGenomics
MBS652588-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Small intestine, BioGenomics
MBS652588-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Brain, Pituitary, BioGenomics
MBS651901-10Tests	MyBiosource	10Tests	EUR 550

Tissue cDNA, First Strand, Human Adult Normal, Brain, Pituitary, BioGenomics
MBS651901-5x10Tests	MyBiosource	5x10Tests	EUR 2255

Tissue cDNA, First Strand, Human Adult Normal, Colon descending, BioGenomics
MBS652112-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Colon descending, BioGenomics
MBS652112-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Colon ascending, BioGenomics
MBS652290-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Colon ascending, BioGenomics
MBS652290-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Lung, BioGenomics
MBS652470-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Lung, BioGenomics
MBS652470-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Colon, BioGenomics
MBS652432-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Rat Adult Normal, Colon, BioGenomics
MBS652432-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Rat Adult Normal, Brain, BioGenomics
MBS651977-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Brain, BioGenomics
MBS651977-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Heart, BioGenomics
MBS651984-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Heart, BioGenomics
MBS651984-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Liver, BioGenomics
MBS652095-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Liver, BioGenomics
MBS652095-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Brain, Hippocampus, BioGenomics
MBS651929-10Reactions	MyBiosource	10Reactions	EUR 550

Tissue cDNA, First Strand, Human Adult Normal, Brain, Hippocampus, BioGenomics
MBS651929-5x10Reactions	MyBiosource	5x10Reactions	EUR 2255

Tissue cDNA, First Strand, Rat Adult Normal, Spleen, BioGenomics
MBS652466-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Spleen, BioGenomics
MBS652466-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Testis, BioGenomics
MBS652483-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Testis, BioGenomics
MBS652483-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Mouse Adult Normal, Lung, BioGenomics
MBS652000-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Mouse Adult Normal, Lung, BioGenomics
MBS652000-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Rectum, BioGenomics
MBS652009-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Rat Adult Normal, Rectum, BioGenomics
MBS652009-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Rat Adult Normal, Kidney, BioGenomics
MBS652090-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Kidney, BioGenomics
MBS652090-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Liver, Left Lobe, BioGenomics
MBS652382-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Liver, Left Lobe, BioGenomics
MBS652382-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Tumor, Stomach, BioGenomics
MBS652291-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Human Tumor, Stomach, BioGenomics
MBS652291-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Mouse Adult Normal, Colon, BioGenomics
MBS652314-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Mouse Adult Normal, Colon, BioGenomics
MBS652314-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Mouse Adult Normal, Heart, BioGenomics
MBS652497-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Mouse Adult Normal, Heart, BioGenomics
MBS652497-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Mouse Adult Normal, Liver, BioGenomics
MBS651975-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Mouse Adult Normal, Liver, BioGenomics
MBS651975-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Mouse Adult Normal, Brain, BioGenomics
MBS651994-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Mouse Adult Normal, Brain, BioGenomics
MBS651994-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Canine Adult Normal, Lung, BioGenomics
MBS652012-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Canine Adult Normal, Lung, BioGenomics
MBS652012-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Bladder, BioGenomics
MBS652086-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Rat Adult Normal, Bladder, BioGenomics
MBS652086-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Rat Adult Normal, Adipose, BioGenomics
MBS652230-40Tests	MyBiosource	40Tests	EUR 850

Tissue cDNA, First Strand, Rat Adult Normal, Adipose, BioGenomics
MBS652230-5x40Tests	MyBiosource	5x40Tests	EUR 3600

Tissue cDNA, First Strand, Human Adult Normal, Heart, Atrium (left), BioGenomics
MBS652342-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Heart, Atrium (left), BioGenomics
MBS652342-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Liver, Right Lobe, BioGenomics
MBS652391-40Tests	MyBiosource	40Tests	EUR 680

Tissue cDNA, First Strand, Human Adult Normal, Liver, Right Lobe, BioGenomics
MBS652391-5x40Tests	MyBiosource	5x40Tests	EUR 2835

Tissue cDNA, First Strand, Human Adult Normal, Heart, Aorta Valve, BioGenomics
MBS651939-10Tests	MyBiosource	10Tests	EUR 540

Tissue cDNA, First Strand, Human Adult Normal, Heart, Aorta Valve, BioGenomics
MBS651939-5x10Tests	MyBiosource	5x10Tests	EUR 2215

NAD is the substrate for CD157- and CD38 dependent cADPR production. nicotinamide riboside correcting social deficits and fear and anxiety-like behavior in male KO CD157. These results indicate that elevate NAD with nicotinamide riboside allow animals to cADPR- and OT-up the deficit to overcome this deficit and a more normal function.