The Jeff Mouse Mutant Model for Chronic Otitis Media Manifests Gain-of-Function as Well as Loss-of-Function Effects

Chronic otitis media (OM) is the most common cause of hearing loss worldwide, but the underlying genetic and molecular pathology are poorly understood. Jeff mutant mouse is a mouse model for OM identified a single gene on the screen deaf as part of an ENU mutagenesis program at MRC Harwell. Jeff brings a missense mutation in the gene Fbxo11. Jeff heterozygous (Fbxo11 Jf / +) develop chronic OM at weaning and have reduced hearing.

Homozygous (Fbxo11 Jf / Jf) display perinatal lethal for the development of epithelial abnormality. In order to investigate the role FBXO11 and type of mutation responsible for the phenotype of mice Jeff, knock-out mouse models are created and compared to Jeff. Surprisingly, heterozygous knock-out (Fbxo11 tm2b / +) showed milder phenotype: they did not display any auditory deficits, and only some of them have thickened epithelial lining of the middle ear without fluid in the ear. In addition, the knock-out embryos homozygous (Fbxo11 tm2b / tm2b), as well as compound heterozygotes (Fbxo11 tm2b / Jf) show only mild abnormalities compared with homozygous Jeff (Fbxo11 Jf / Jf).

Interestingly, three days after inoculation intranasally of Fbxo11 tm2b / + mice with non-typeable Haemophilus influenzae (NTHI) proportion of them have been inflamed mucosa of the middle ear and accumulation of fluid in the ear indicates that Fbxo11 knock-out mice tend to NTHI induced inflammation of the middle ear. In conclusion, the finding that the mutant phenotype Jeff is much more severe than the knock-out show that a mutation in the manifest Jeff gain-of-function and loss-of-function effects on both embryonic and adult stages.

Congenital heart disease (CHD) affects nearly one percent of all live births. Despite advances in diagnostic and reparative surgery, causes and mechanisms of CHD is still mainly unknown. Extracellular matrix plays a major role in cell communication, function, and differentiation, and therefore may play a role in disease development and pathophysiology.

Cell adhesion and gap junction proteins, such as integrins and connexins, are also important for mobile communication and behavior, and can interact directly (integrins) or indirectly (connexins) with the extracellular matrix. In this work, we explore the gaps in the spatial pattern of expression and extracellular matrix, adhesion and gap junction protein between wild-type and Nkx2-5 + / RG mutant mice.

Nicotinamide riboside supplementation corrects deficits in oxytocin, socialization and anxiety of CD157 mutants in a mouse model of autism spectrum disorder

Oxytocin (OT) is an important molecule for social recognition and memory in social and emotional mediate behavior. In addition, PL act as a factor of anxiolytic and released during stress. Based on the activity of the enzyme that produces CD38 as calcium-mobilizing second messenger cyclic ADP-ribose (cADPR), CD157, CD38 sister protein, has been considered as candidate mediators for the production and release of OT and social engagement and anti-anxiety function.

However, the limited expression of CD157 in the adult rat brain undermines the trust participants molecule CD157 is authentic and / or followed up in social behavior OT-dependent. Here, we show that CD157 knockout mice had lower levels of circulating PL in the cerebrospinal fluid, which can be corrected by oral administration of nicotinamide riboside, vitamin precursor of nicotinamide adenine newfound dinucleotide (NAD).

cDNA from Human Adult Normal Tissue: Stomach: Pylorus
C1234253-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Stomach
C1334248	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Stomach
C1434248	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Stomach
C1734248	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

miRNA First-Strand cDNA Synthesis SuperMix
abx098020-20rxns20ulSystems	Abbexa	20 rxns × 20 ul Systems	EUR 878.4

Fly First-Strand cDNA Synthesis SuperMix
20-abx09885820ulSystems	Abbexa	EUR 861.60 EUR 693.60	100 rxns × 20 ul Systems 50 rxns × 20 ul Systems

Optimax First Strand cDNA Synthesis Kit
K4201100	Biochain	100 rnx	EUR 502.8

Human Adult Stomach (Normal) Whole tissue lysate
HAL-1319	Alpha Diagnostics	1 mg	EUR 628.8

Paraffin Tissue Section - Human Adult Normal: Stomach
T2234248	Biochain	5 slides	EUR 253.2
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

Frozen Tissue Section - Human Adult Normal: Stomach
T1234248	Biochain	5 slides	EUR 418.8
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool.

cDNA from Monkey (Rhesus) Normal Tissue: Stomach
C1534248	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Cynomolgus) Normal Tissue: Stomach
C1534248-Cy	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Adipose
C1234003-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Adrenal
C1234004	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Bladder
C1234010	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain
C1234035	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Breast
C1234086	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Colon
C1234090	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Esophagus
C1234106	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Heart
C1234122	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Kidney
C1234142	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Liver
C1234149	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Lung
C1234152	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Trachea
C1234160-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Ovary
C1234183	Biochain	40 reactions	EUR 1126.8
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Pancreas
C1234188	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Placenta
C1234200	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Prostate
C1234201	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Rectum
C1234206	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Skin
C1234218	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Spleen
C1234246	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Testis
C1234260	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Theca
C1234261-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Throat
C1234263-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Thymus
C1234264	Biochain	40 reactions	EUR 1126.8
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Thyroid
C1234265	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Tongue
C1234267-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Tonsil
C1234268-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Uterus
C1234274	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

First-Strand cDNA Synthesis SuperMix for PCR
abx098018-50rxns20ulSystems	Abbexa	50 rxns × 20 ul Systems	EUR 693.6

Total Protein from Human Adult Normal Tissue: Stomach
P1234248	Biochain	1 mg	EUR 256.8
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Human Adult Normal Tissue: Stomach
P3234248	Biochain	0.1 mg	EUR 342
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Human Adult Normal Tissue: Stomach
R1234248-50	Biochain	50 ug	EUR 213.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Stomach: Cardia
C1534250	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Stomach: Corpus
C1534251	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Stomach: Fundus
C1534252	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Monkey (Rhesus) Normal Tissue: Stomach: Pylorus
C1534253	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Bone Marrow
C1234024-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Amygdala
C1234036-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Cerebellum
C1234039	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Hippocampus
C1234052-10	Biochain	10 reactions	EUR 324
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Pituitary
C1234068-10	Biochain	10 reactions	EUR 324
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Pons
C1234071-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Colon Ascending
C1234091	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Colon Descending
C1234092	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Colon Sigmoid
C1234095	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Colon Transverse
C1234096	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Whole Eye
C1234108-10	Biochain	10 reactions	EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Eye: Retina
C1234110-10	Biochain	10 reactions	EUR 535.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Fallopian Tube
C1234115-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Lymph Node
C1234161-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Skeletal Muscle
C1234171	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Salivary Gland
C1234212-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Small Intestine
C1234226	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Spinal Cord
C1234234	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Uterus: Cervix
C1234275	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Uterus: Corpus
C1234276-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Uterus: Fundus
C1234278-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

First-Strand cDNA Synthesis SuperMix (cDNA up to 12 kb)
20-abx09801620ulSystems	Abbexa	EUR 744.00 EUR 627.60	100 rxns × 20 ul Systems 50 rxns × 20 ul Systems

First-Strand cDNA Synthesis SuperMix (cDNA up to 15 kb)
20-abx09802120ulSystems	Abbexa	EUR 1045.20 EUR 794.40	100 rxns × 20 ul Systems 50 rxns × 20 ul Systems

igScript First Strand cDNA Synthesis Kit - 25 Reactions
4312	Intact Genomics	1/EA	EUR 178.8

igScript First Strand cDNA Synthesis Kit - 100 Reactions
4314	Intact Genomics	1/EA	EUR 453.6

Accuris qMAX First Strand cDNA Synthesis Flex Kit
PR2110-200	Benchmark Scientific	1 PC	EUR 405.3

Accuris qMAX First Strand cDNA Synthesis Flex Kit
PR2110-50	Benchmark Scientific	1 PC	EUR 159.35

Accuris qMAX First Strand cDNA Synthesis Flex Kit
PR2110-S	Benchmark Scientific	1 PC	EUR 87.58

Total Protein from Human Adult Normal Tissue: Stomach: Cardia
P1234250	Biochain	1 mg	EUR 256.8
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Human Adult Normal Tissue: Stomach: Corpus
P1234251	Biochain	1 mg	EUR 256.8
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Human Adult Normal Tissue: Stomach: Fundus
P1234252	Biochain	1 mg	EUR 256.8
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total Protein from Human Adult Normal Tissue: Stomach: Pylorus
P1234253	Biochain	1 mg	EUR 256.8
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Human Adult Normal Tissue: Stomach: Cardia
P3234250	Biochain	0.1 mg	EUR 342
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Human Adult Normal Tissue: Stomach: Corpus
P3234251	Biochain	0.1 mg	EUR 342
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Human Adult Normal Tissue: Stomach: Fundus
P3234252	Biochain	0.1 mg	EUR 342
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Membrane Protein from Human Adult Normal Tissue: Stomach: Pylorus
P3234253	Biochain	0.1 mg	EUR 342
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation.

Total RNA from Human Adult Normal Tissue: Stomach: Cardia
R1234250-10	Biochain	10 ug	EUR 232.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Stomach: Corpus
R1234251-10	Biochain	10 ug	EUR 232.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Stomach: Fundus
R1234252-10	Biochain	10 ug	EUR 232.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue: Stomach: Pylorus
R1234253-10	Biochain	10 ug	EUR 232.8
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

Chicken (Normal/Adult) Universal (pool of tissue cDNA)
CHUC-565	Alpha Diagnostics	10 rxn	EUR 498

cDNA from Human Adult Normal Tissue: Blood Vessel: Artery
C1234013-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Blood Vessel: Vein
C1234020-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Cerebellum (left)
C1234040-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Cerebellum (right)
C1234041-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Cerebral Cortex
C1234042-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Corpus Callosum
C1234045-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Olfactory (region)
C1234063-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Brain: Vermis Cerebelli
C1234082-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Small Intestine: Duodenum
C1234101-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Heart: Aorta Valve
C1234123-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Heart: Atrium (left)
C1234126	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Heart: Atrium (right)
C1234127	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Heart: Ventricle (left)
C1234138	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Heart: Ventricle (right)
C1234139	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Peripheral Blood Leukocyte
C1234148-10	Biochain	10 reactions	EUR 277.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Liver: Left Lobe
C1234150	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Liver: Right Lobe
C1234151	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Small Intestine: Ileum
C1234227	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Small Intestine: Jejunum
C1234230	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Human Adult cDNA Tissue: Lung
HA-152	Alpha Diagnostics	10 rxn	EUR 498

Human Adult cDNA Tissue: Skin
HA-218	Alpha Diagnostics	10 rxn	EUR 498

Human Adult cDNA Tissue: Testis
HA-260	Alpha Diagnostics	10 rxn	EUR 498

Stomach Tissue Slide (Normal)
10-801-10um	ProSci	10 um	EUR 241.8

Stomach Tissue Slide (Normal)
10-801-4um	ProSci	4 um	EUR 216.6

Stomach Tissue Lysate (Normal)
1717-01	ProSci	0.1 mg	EUR 260.7
Description: Stomach tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Normal stomach tissue array
BN01011b	TissueArray	each	EUR 222
Description: Normal stomach tissue array, 24 cases/72 cores, replacing BN01011

cDNA from Human Tumor Tissue: Stomach
C1235248	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Diabetic Tissue: Stomach
C1236248Dia	Biochain	40 reactions	EUR 801.6
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Lung: Left Lower Lobe
C1234155	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Lung: Left Upper Lobe
C1234156	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Lung: Right Lower Lobe
C1234157	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Lung: Right Middle Lobe
C1234158	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Human Adult Normal Tissue: Lung: Right Upper Lobe
C1234159	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Matching Pair - cDNA from Human Primary Tumor and Normal Tissue: Stomach
C8235248-PP	Biochain	10 reactions x2	EUR 598.8
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Total RNA from Human Adult Normal Tissue 5 Donor Pool: Stomach
R1234248-P	Biochain	50 ug	EUR 393.6
Description: Can be used for various studies in the realm of gene expression and regulation, both normal and pathological. It is an excellent control and suitable for educational purposes.

All-in-One First-Strand cDNA Synthesis SuperMix for PCR
abx098023-50rxns20ulSystems	Abbexa	50 rxns × 20 ul Systems	EUR 878.4

Stomach cancer tissue array with matched adjacent normal stomach tissue
ST801b	TissueArray	each	EUR 270
Description: Stomach cancer tissue array with matched adjacent normal stomach tissue, including pathology grade, TNM and clinical stage, 40 cases/80 cores, replacing ST801a

Normal stomach tissue and duodenum tissue array
SIN241	TissueArray	each	EUR 198
Description: Normal stomach tissue and duodenum tissue array, 24 cases/ 24 cores

Genomic DNA from Human Adult Normal Tissue: Stomach, from a single donor
D1234248	Biochain	100 ug	EUR 338.4
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

Stomach cancer with adjacent normal tissue and normal tissue array
ST2082a	TissueArray	each	EUR 474
Description: Stomach cancer with adjacent normal tissue and normal tissue array, including pathology grade, TNM and clinical stage, 96 cases/192 cores, replacing ST2082

Stomach cancer with normal tissue array
ST2083	TissueArray	each	EUR 546
Description: Stomach cancer with normal tissue array, including pathology grade, TNM and clinical stage, 69 cases/207 cores

Human Stomach Tissue Preparation Buffer: Normal Stomach Mucosa Epithelial Cells
9-80104	CHI Scientific	1 x 100 ml	Ask for price

Stomach cancer with matched adjacent normal stomach tissue array
ST244b	TissueArray	each	EUR 78
Description: Stomach cancer with matched adjacent normal stomach tissue array, including pathology grade, TNM and clinical stage, 6cases/24cores, replacing ST244a

cDNA from Mouse Normal Tissue: Adipose
C1334003	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Bladder
C1334010	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Brain
C1334035	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Colon
C1334090	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Heart
C1334122	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Kidney
C1334142	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Liver
C1334149	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Lung
C1334152	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Placenta
C1334200	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Rectum
C1334206	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Spleen
C1334246	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Mouse Normal Tissue: Testis
C1334260	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Adipose
C1434003	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Bladder
C1434010	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Brain
C1434035	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Colon
C1434090	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Heart
C1434122	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Kidney
C1434142	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Liver
C1434149	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Lung
C1434152	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Placenta
C1434200	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Rectum
C1434206	Biochain	40 reactions	EUR 648
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Spleen
C1434246	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Rat Normal Tissue: Testis
C1434260	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Bladder
C1734010	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Brain
C1734035	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Cecum
C1734089	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Esophagus
C1734106	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Heart
C1734122	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Kidney
C1734142	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Liver
C1734149	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

cDNA from Dog Normal Tissue: Lung
C1734152	Biochain	40 reactions	EUR 451.2
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes.

NAD is the substrate for CD157- and CD38 dependent cADPR production. nicotinamide riboside correcting social deficits and fear and anxiety-like behavior in male KO CD157. These results indicate that elevate NAD with nicotinamide riboside allow animals to cADPR- and OT-up the deficit to overcome this deficit and a more normal function.